Chan CH - Search Results

1

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.

Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Chan CH, et al. Cell. 2013 Aug 1;154(3):556-68. doi: 10.1016/j.cell.2013.06.048. Cell. 2013. PMID: 23911321 Free PMC article.

2

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.

Jin G, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov dos D, Ho YS, Lin HK. Jin G, et al. Among authors: chan ch. Mol Cell. 2015 Jun 18;58(6):989-1000. doi: 10.1016/j.molcel.2015.05.010. Epub 2015 Jun 4. Mol Cell. 2015. PMID: 26051179 Free PMC article.

3

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.

Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Chan CH, et al. Nat Cell Biol. 2010 May;12(5):457-67. doi: 10.1038/ncb2047. Epub 2010 Apr 11. Nat Cell Biol. 2010. PMID: 20383141 Free PMC article.

4

Regulation of Skp2 expression and activity and its role in cancer progression.

Chan CH, Lee SW, Wang J, Lin HK. Chan CH, et al. ScientificWorldJournal. 2010 Jun 1;10:1001-15. doi: 10.1100/tsw.2010.89. ScientificWorldJournal. 2010. PMID: 20526532 Free PMC article. Review.

5

The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal.

Wang J, Han F, Wu J, Lee SW, Chan CH, Wu CY, Yang WL, Gao Y, Zhang X, Jeong YS, Moten A, Samaniego F, Huang P, Liu Q, Zeng YX, Lin HK. Wang J, et al. Among authors: chan ch. Blood. 2011 Nov 17;118(20):5429-38. doi: 10.1182/blood-2010-10-312785. Epub 2011 Sep 19. Blood. 2011. PMID: 21931116 Free PMC article.

6

Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis.

Wang G, Chan CH, Gao Y, Lin HK. Wang G, et al. Among authors: chan ch. Chin J Cancer. 2012 Apr;31(4):169-77. doi: 10.5732/cjc.011.10319. Epub 2011 Dec 23. Chin J Cancer. 2012. PMID: 22200179 Free PMC article. Review.

7

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. Chan CH, et al. Cell. 2012 May 25;149(5):1098-111. doi: 10.1016/j.cell.2012.02.065. Cell. 2012. PMID: 22632973 Free PMC article.

8

Skp2: a dream target in the coming age of cancer therapy.

Chan CH, Morrow JK, Zhang S, Lin HK. Chan CH, et al. Cell Cycle. 2014;13(5):679-80. doi: 10.4161/cc.27853. Epub 2014 Jan 21. Cell Cycle. 2014. PMID: 24526126 Free PMC article. No abstract available.

9

E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing.

Wang J, Han F, Lee SW, Wu J, Chan CH, Zhang X, Gao Y, Su HK, Feng ZZ, Xu DZ, Lin HK. Wang J, et al. Among authors: chan ch. Biochem Biophys Res Commun. 2014 Mar 14;445(3):566-71. doi: 10.1016/j.bbrc.2014.02.042. Epub 2014 Feb 18. Biochem Biophys Res Commun. 2014. PMID: 24561244

10

Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.

Lee SW, Li CF, Jin G, Cai Z, Han F, Chan CH, Yang WL, Li BK, Rezaeian AH, Li HY, Huang HY, Lin HK. Lee SW, et al. Among authors: chan ch. Mol Cell. 2015 Mar 19;57(6):1022-1033. doi: 10.1016/j.molcel.2015.01.015. Epub 2015 Feb 26. Mol Cell. 2015. PMID: 25728766 Free PMC article.

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