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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. Among authors: wang l. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension.
Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Merklinger SL, et al. Among authors: wang l. Circ Res. 2005 Sep 16;97(6):596-604. doi: 10.1161/01.RES.0000182425.49768.8a. Epub 2005 Aug 18. Circ Res. 2005. PMID: 16109920
Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling.
El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M. El-Bizri N, et al. Among authors: wang l. Circ Res. 2008 Feb 15;102(3):380-8. doi: 10.1161/CIRCRESAHA.107.161059. Epub 2007 Dec 13. Circ Res. 2008. PMID: 18079409 Free PMC article.
Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.
Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M. Spiekerkoetter E, et al. Among authors: wang l. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L276-89. doi: 10.1152/ajplung.00414.2007. Epub 2007 Dec 14. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18083765 Free article.
S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4.
Spiekerkoetter E, Guignabert C, de Jesus Perez V, Alastalo TP, Powers JM, Wang L, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M, Ashley RH, Rabinovitch M. Spiekerkoetter E, et al. Among authors: wang l. Circ Res. 2009 Sep 25;105(7):639-47, 13 p following 647. doi: 10.1161/CIRCRESAHA.109.205120. Epub 2009 Aug 27. Circ Res. 2009. PMID: 19713532 Free PMC article.
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