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A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
Rienhoff HY Jr, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M. Rienhoff HY Jr, et al. Among authors: westwick j. Am J Med Genet A. 2013 Aug;161A(8):2040-6. doi: 10.1002/ajmg.a.36056. Epub 2013 Jul 3. Am J Med Genet A. 2013. PMID: 23824657 Free PMC article.
Identifying off-target effects and hidden phenotypes of drugs in human cells.
MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK. MacDonald ML, et al. Among authors: westwick jk. Nat Chem Biol. 2006 Jun;2(6):329-37. doi: 10.1038/nchembio790. Epub 2006 May 7. Nat Chem Biol. 2006. PMID: 16680159
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T. Murray BW, et al. Among authors: westwick jk. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. doi: 10.1073/pnas.0911863107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439741 Free PMC article.
JNK mediates hepatic ischemia reperfusion injury.
Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA. Uehara T, et al. J Hepatol. 2005 Jun;42(6):850-9. doi: 10.1016/j.jhep.2005.01.030. Epub 2005 Apr 7. J Hepatol. 2005. PMID: 15885356
221 results