Lessene G - Search Results

1

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, Wei A, Huang DC, Colman PM, Street IP, Baell JB, Watson K, Lessene G. Sleebs BE, et al. Among authors: lessene g. J Med Chem. 2013 Jul 11;56(13):5514-40. doi: 10.1021/jm400556w. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23767404

2

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.

He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, Kawakami, Hsieh CY, Kung HJ, Lessene G, Baell J, Levitzki A, Maruta H. He H, et al. Among authors: lessene g. Cancer Biol Ther. 2004 Jan;3(1):96-101. doi: 10.4161/cbt.3.1.643. Epub 2004 Jan 29. Cancer Biol Ther. 2004. PMID: 14726663

3

A concise total synthesis of naamidine A.

Aberle NS, Lessene G, Watson KG. Aberle NS, et al. Among authors: lessene g. Org Lett. 2006 Feb 2;8(3):419-21. doi: 10.1021/ol052568o. Org Lett. 2006. PMID: 16435849

4

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).

Hirokawa Y, Levitzki A, Lessene G, Baell J, Xiao Y, Zhu H, Maruta H. Hirokawa Y, et al. Among authors: lessene g. Cancer Lett. 2007 Jan 8;245(1-2):242-51. doi: 10.1016/j.canlet.2006.01.018. Epub 2006 Mar 15. Cancer Lett. 2007. PMID: 16540233

5

Effects of modulators of Ca(2+)-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo.

Ferens D, Baell J, Lessene G, Smith JE, Furness JB. Ferens D, et al. Among authors: lessene g. Neurogastroenterol Motil. 2007 May;19(5):383-9. doi: 10.1111/j.1365-2982.2007.00898.x. Neurogastroenterol Motil. 2007. PMID: 17509020

6

BCL-2 family antagonists for cancer therapy.

Lessene G, Czabotar PE, Colman PM. Lessene G, et al. Nat Rev Drug Discov. 2008 Dec;7(12):989-1000. doi: 10.1038/nrd2658. Nat Rev Drug Discov. 2008. PMID: 19043450 Review.

7

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange.

Lessene G, Smith BJ, Gable RW, Baell JB. Lessene G, et al. J Org Chem. 2009 Sep 4;74(17):6511-25. doi: 10.1021/jo900871a. J Org Chem. 2009. PMID: 19711992

8

Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.

Lee EF, Czabotar PE, Yang H, Sleebs BE, Lessene G, Colman PM, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: lessene g. J Biol Chem. 2009 Oct 30;284(44):30508-17. doi: 10.1074/jbc.M109.040725. Epub 2009 Sep 2. J Biol Chem. 2009. PMID: 19726685 Free PMC article.

9

Bcl-2 family proteins as therapeutic targets.

Czabotar PE, Lessene G. Czabotar PE, et al. Among authors: lessene g. Curr Pharm Des. 2010;16(28):3132-48. doi: 10.2174/138161210793292429. Curr Pharm Des. 2010. PMID: 20687882 Review.

10

Benzoylureas as removable cis amide inducers: synthesis of cyclic amides via ring closing metathesis (RCM).

Brady RM, Khakham Y, Lessene G, Baell JB. Brady RM, et al. Among authors: lessene g. Org Biomol Chem. 2011 Feb 7;9(3):656-8. doi: 10.1039/c0ob00723d. Epub 2010 Nov 18. Org Biomol Chem. 2011. PMID: 21088766

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