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Page 1
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.
Amorós I, Dolz-Gaitón P, Gómez R, Matamoros M, Barana A, de la Fuente MG, Núñez M, Pérez-Hernández M, Moraleda I, Gálvez E, Iriepa I, Tamargo J, Caballero R, Delpón E. Amorós I, et al. Among authors: dolz gaiton p. Biochem Pharmacol. 2013 Jul 15;86(2):267-78. doi: 10.1016/j.bcp.2013.04.023. Epub 2013 May 3. Biochem Pharmacol. 2013. PMID: 23648307
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.
Caballero R, Dolz-Gaitón P, Gómez R, Amorós I, Barana A, González de la Fuente M, Osuna L, Duarte J, López-Izquierdo A, Moraleda I, Gálvez E, Sánchez-Chapula JA, Tamargo J, Delpón E. Caballero R, et al. Among authors: dolz gaiton p. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15631-6. doi: 10.1073/pnas.1004021107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713726 Free PMC article.
Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome.
Amorós I, Jiménez-Jáimez J, Tercedor L, Barana A, Gómez R, de la Fuente MG, Dolz-Gaitón P, Alvarez M, Martínez-Espín E, Lorente JA, Melgares R, Tamargo J, Delpón E, Caballero R. Amorós I, et al. Among authors: dolz gaiton p. Heart Rhythm. 2011 Mar;8(3):463-70. doi: 10.1016/j.hrthm.2010.11.032. Epub 2010 Nov 23. Heart Rhythm. 2011. PMID: 21109023
In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both.
Caballero R, de la Fuente MG, Gómez R, Barana A, Amorós I, Dolz-Gaitón P, Osuna L, Almendral J, Atienza F, Fernández-Avilés F, Pita A, Rodríguez-Roda J, Pinto A, Tamargo J, Delpón E. Caballero R, et al. J Am Coll Cardiol. 2010 May 25;55(21):2346-54. doi: 10.1016/j.jacc.2010.02.028. J Am Coll Cardiol. 2010. PMID: 20488306 Free article.
Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration.
González de la Fuente M, Barana A, Gómez R, Amorós I, Dolz-Gaitón P, Sacristán S, Atienza F, Pita A, Pinto Á, Fernández-Avilés F, Caballero R, Tamargo J, Delpón E. González de la Fuente M, et al. Among authors: dolz gaiton p. Cardiovasc Res. 2013 Feb 1;97(2):379-88. doi: 10.1093/cvr/cvs313. Epub 2012 Oct 11. Cardiovasc Res. 2013. PMID: 23060133
Functional characterization of a novel frameshift mutation in the C-terminus of the Nav1.5 channel underlying a Brugada syndrome with variable expression in a Spanish family.
Dolz-Gaitón P, Núñez M, Núñez L, Barana A, Amorós I, Matamoros M, Pérez-Hernández M, González de la Fuente M, Alvarez-López M, Macías-Ruiz R, Tercedor-Sánchez L, Jiménez-Jáimez J, Delpón E, Caballero R, Tamargo J. Dolz-Gaitón P, et al. PLoS One. 2013 Nov 25;8(11):e81493. doi: 10.1371/journal.pone.0081493. eCollection 2013. PLoS One. 2013. PMID: 24363796 Free PMC article.
Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.
Barana A, Matamoros M, Dolz-Gaitón P, Pérez-Hernández M, Amorós I, Núñez M, Sacristán S, Pedraz Á, Pinto Á, Fernández-Avilés F, Tamargo J, Delpón E, Caballero R. Barana A, et al. Among authors: dolz gaiton p. Circ Arrhythm Electrophysiol. 2014 Oct;7(5):861-8. doi: 10.1161/CIRCEP.114.001709. Epub 2014 Aug 8. Circ Arrhythm Electrophysiol. 2014. PMID: 25107449
12 results