Baell JB - Search Results

1

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG. Lessene G, et al. Among authors: baell jb. Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21. Nat Chem Biol. 2013. PMID: 23603658

2

Biased receptor signalling and intracellular trafficking profiles of structurally distinct formylpeptide receptor 2 agonists.

Peng C, Vecchio EA, Nguyen ATN, De Seram M, Tang R, Keov P, Woodman OL, Chen YC, Baell J, May LT, Zhao P, Ritchie RH, Qin CX. Peng C, et al. Br J Pharmacol. 2024 Aug 18. doi: 10.1111/bph.17310. Online ahead of print. Br J Pharmacol. 2024. PMID: 39154373

3

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs.

Baell JB, Huang DC. Baell JB, et al. Biochem Pharmacol. 2002 Sep;64(5-6):851-63. doi: 10.1016/s0006-2952(02)01148-6. Biochem Pharmacol. 2002. PMID: 12213579 Review.

4

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.

He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, Kawakami, Hsieh CY, Kung HJ, Lessene G, Baell J, Levitzki A, Maruta H. He H, et al. Cancer Biol Ther. 2004 Jan;3(1):96-101. doi: 10.4161/cbt.3.1.643. Epub 2004 Jan 29. Cancer Biol Ther. 2004. PMID: 14726663

5

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).

Hirokawa Y, Levitzki A, Lessene G, Baell J, Xiao Y, Zhu H, Maruta H. Hirokawa Y, et al. Cancer Lett. 2007 Jan 8;245(1-2):242-51. doi: 10.1016/j.canlet.2006.01.018. Epub 2006 Mar 15. Cancer Lett. 2007. PMID: 16540233

6

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.

Holloway GA, Baell JB, Fairlamb AH, Novello PM, Parisot JP, Richardson J, Watson KG, Street IP. Holloway GA, et al. Among authors: baell jb. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1422-7. doi: 10.1016/j.bmcl.2006.11.090. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17194585 Free PMC article.

7

Effects of modulators of Ca(2+)-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo.

Ferens D, Baell J, Lessene G, Smith JE, Furness JB. Ferens D, et al. Among authors: baell j. Neurogastroenterol Motil. 2007 May;19(5):383-9. doi: 10.1111/j.1365-2982.2007.00898.x. Neurogastroenterol Motil. 2007. PMID: 17509020

8

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB. Holloway GA, et al. Among authors: baell jb. Antimicrob Agents Chemother. 2009 Jul;53(7):2824-33. doi: 10.1128/AAC.01568-08. Epub 2009 Apr 13. Antimicrob Agents Chemother. 2009. PMID: 19364854 Free PMC article.

9

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange.

Lessene G, Smith BJ, Gable RW, Baell JB. Lessene G, et al. Among authors: baell jb. J Org Chem. 2009 Sep 4;74(17):6511-25. doi: 10.1021/jo900871a. J Org Chem. 2009. PMID: 19711992

10

Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library.

Lackovic K, Parisot JP, Sleebs N, Baell JB, Debien L, Watson KG, Curtis JM, Handman E, Street IP, Kedzierski L. Lackovic K, et al. Among authors: baell jb. Antimicrob Agents Chemother. 2010 May;54(5):1712-9. doi: 10.1128/AAC.01634-09. Epub 2010 Feb 16. Antimicrob Agents Chemother. 2010. PMID: 20160053 Free PMC article.

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