Martin MP - Search Results

1

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.

Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, Georg GI. Schonbrunn E, et al. Among authors: martin mp. J Med Chem. 2013 May 23;56(10):3768-82. doi: 10.1021/jm301234k. Epub 2013 May 6. J Med Chem. 2013. PMID: 23600925 Free PMC article.

2

Discovery of a potential allosteric ligand binding site in CDK2.

Betzi S, Alam R, Martin M, Lubbers DJ, Han H, Jakkaraj SR, Georg GI, Schönbrunn E. Betzi S, et al. ACS Chem Biol. 2011 May 20;6(5):492-501. doi: 10.1021/cb100410m. Epub 2011 Feb 22. ACS Chem Biol. 2011. PMID: 21291269 Free PMC article.

3

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

Martin MP, Zhu JY, Lawrence HR, Pireddu R, Luo Y, Alam R, Ozcan S, Sebti SM, Lawrence NJ, Schönbrunn E. Martin MP, et al. ACS Chem Biol. 2012 Apr 20;7(4):698-706. doi: 10.1021/cb200508b. Epub 2012 Jan 27. ACS Chem Biol. 2012. PMID: 22248356 Free PMC article.

4

Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.

Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Li R, et al. Among authors: martin mp. J Med Chem. 2012 Mar 8;55(5):2474-8. doi: 10.1021/jm201289r. Epub 2012 Feb 15. J Med Chem. 2012. PMID: 22272748 Free PMC article.

5

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM. Patel RA, et al. Among authors: martin mp. Cancer Res. 2012 Oct 1;72(19):5025-34. doi: 10.1158/0008-5472.CAN-12-0954. Epub 2012 Jul 30. Cancer Res. 2012. PMID: 22846914 Free PMC article.

6

A novel approach to the discovery of small-molecule ligands of CDK2.

Martin MP, Alam R, Betzi S, Ingles DJ, Zhu JY, Schönbrunn E. Martin MP, et al. Chembiochem. 2012 Sep 24;13(14):2128-36. doi: 10.1002/cbic.201200316. Epub 2012 Aug 14. Chembiochem. 2012. PMID: 22893598 Free PMC article.

7

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

Pireddu R, Forinash KD, Sun NN, Martin MP, Sung SS, Alexander B, Zhu JY, Guida WC, Schönbrunn E, Sebti SM, Lawrence NJ. Pireddu R, et al. Among authors: martin mp. Medchemcomm. 2012 Jun 1;3(6):699-709. doi: 10.1039/C2MD00320A. Epub 2012 Jan 27. Medchemcomm. 2012. PMID: 23275831 Free PMC article.

8

Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains.

Martin MP, Olesen SH, Georg GI, Schönbrunn E. Martin MP, et al. ACS Chem Biol. 2013 Nov 15;8(11):2360-5. doi: 10.1021/cb4003283. Epub 2013 Sep 10. ACS Chem Biol. 2013. PMID: 24007471 Free PMC article.

9

Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors.

Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schönbrunn E. Ember SW, et al. Among authors: martin mp. ACS Chem Biol. 2014 May 16;9(5):1160-71. doi: 10.1021/cb500072z. Epub 2014 Mar 13. ACS Chem Biol. 2014. PMID: 24568369 Free PMC article.

10

Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2.

Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Schönbrunn E. Olesen SH, et al. Among authors: martin mp. Molecules. 2015 Jan 19;20(1):1643-60. doi: 10.3390/molecules20011643. Molecules. 2015. PMID: 25608045 Free PMC article.

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