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Discovery of a selective irreversible BMX inhibitor for prostate cancer.
Liu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, Zhao Z, Wang W, Mao M, Cai C, Simon NI, Sanda T, Wang J, Look AT, Griffin JD, Balk SP, Liu Q, Gray NS. Liu F, et al. Among authors: chen s. ACS Chem Biol. 2013 Jul 19;8(7):1423-8. doi: 10.1021/cb4000629. Epub 2013 Apr 26. ACS Chem Biol. 2013. PMID: 23594111
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, Marck B, Matsumoto AM, Simon NI, Wang H, Chen S, Balk SP. Cai C, et al. Among authors: chen s. Cancer Res. 2011 Oct 15;71(20):6503-13. doi: 10.1158/0008-5472.CAN-11-0532. Epub 2011 Aug 25. Cancer Res. 2011. PMID: 21868758 Free PMC article.
ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.
Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X. Cai C, et al. Among authors: chen s. J Clin Invest. 2013 Mar;123(3):1109-22. doi: 10.1172/JCI66666. Epub 2013 Feb 15. J Clin Invest. 2013. PMID: 23426182 Free PMC article.
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