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CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy.
Teft WA, Gong IY, Dingle B, Potvin K, Younus J, Vandenberg TA, Brackstone M, Perera FE, Choi YH, Zou G, Legan RM, Tirona RG, Kim RB. Teft WA, et al. Among authors: legan rm. Breast Cancer Res Treat. 2013 May;139(1):95-105. doi: 10.1007/s10549-013-2511-4. Epub 2013 Apr 12. Breast Cancer Res Treat. 2013. PMID: 23580071
Impact of pretreatment dihydropyrimidine dehydrogenase genotype-guided fluoropyrimidine dosing on chemotherapy associated adverse events.
Wigle TJ, Povitz BL, Medwid S, Teft WA, Legan RM, Lenehan J, Nevison S, Panuganty V, Keller D, Mailloux J, Siebring V, Sarma S, Choi YH, Welch S, Winquist E, Schwarz UI, Kim RB. Wigle TJ, et al. Among authors: legan rm. Clin Transl Sci. 2021 Jul;14(4):1338-1348. doi: 10.1111/cts.12981. Epub 2021 Feb 23. Clin Transl Sci. 2021. PMID: 33620159 Free PMC article.