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A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.
Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T. Cohen RM, et al. Among authors: agadjanyan mg. J Neurosci. 2013 Apr 10;33(15):6245-56. doi: 10.1523/JNEUROSCI.3672-12.2013. J Neurosci. 2013. PMID: 23575824 Free PMC article.
Mimotopes of conformational epitopes in fibrillar beta-amyloid.
Gevorkian G, Petrushina I, Manoutcharian K, Ghochikyan A, Acero G, Vasilevko V, Cribbs DH, Agadjanyan MG. Gevorkian G, et al. Among authors: agadjanyan mg. J Neuroimmunol. 2004 Nov;156(1-2):10-20. doi: 10.1016/j.jneuroim.2004.06.004. J Neuroimmunol. 2004. PMID: 15465592
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG. Mamikonyan G, et al. Among authors: agadjanyan mg. J Biol Chem. 2007 Aug 3;282(31):22376-86. doi: 10.1074/jbc.M700088200. Epub 2007 Jun 1. J Biol Chem. 2007. PMID: 17545160 Free PMC article.
Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.
Petrushina I, Ghochikyan A, Mkrtichyan M, Mamikonyan G, Movsesyan N, Ajdari R, Vasilevko V, Karapetyan A, Lees A, Agadjanyan MG, Cribbs DH. Petrushina I, et al. Among authors: agadjanyan mg. J Neuroinflammation. 2008 Sep 29;5:42. doi: 10.1186/1742-2094-5-42. J Neuroinflammation. 2008. PMID: 18823564 Free PMC article.
86 results