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Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. Kidani Y, et al. Among authors: williams kj. Nat Immunol. 2013 May;14(5):489-99. doi: 10.1038/ni.2570. Epub 2013 Apr 7. Nat Immunol. 2013. PMID: 23563690 Free PMC article.
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.
Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. Williams KJ, et al. Cancer Res. 2013 May 1;73(9):2850-62. doi: 10.1158/0008-5472.CAN-13-0382-T. Epub 2013 Feb 25. Cancer Res. 2013. PMID: 23440422 Free PMC article.
De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.
Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. Akhavan D, et al. Among authors: williams kj. Cancer Discov. 2013 May;3(5):534-47. doi: 10.1158/2159-8290.CD-12-0502. Epub 2013 Mar 26. Cancer Discov. 2013. PMID: 23533263 Free PMC article. Clinical Trial.
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. York AG, et al. Among authors: williams kj. Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10. Cell. 2015. PMID: 26686653 Free PMC article.
Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux.
Meriwether D, Sulaiman D, Wagner A, Grijalva V, Kaji I, Williams KJ, Yu L, Fogelman S, Volpe C, Bensinger SJ, Anantharamaiah GM, Shechter I, Fogelman AM, Reddy ST. Meriwether D, et al. Among authors: williams kj. J Lipid Res. 2016 Jul;57(7):1175-93. doi: 10.1194/jlr.M067025. Epub 2016 May 19. J Lipid Res. 2016. PMID: 27199144 Free PMC article.
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.
Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. Mukherjee P, et al. J Lipid Res. 2017 Aug;58(8):1636-1647. doi: 10.1194/jlr.M076554. Epub 2017 Jun 7. J Lipid Res. 2017. PMID: 28592401 Free PMC article.
643 results