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Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V. De Santo C, et al. Among authors: speak ao. J Clin Invest. 2008 Dec;118(12):4036-48. doi: 10.1172/JCI36264. Epub 2008 Nov 13. J Clin Invest. 2008. PMID: 19033672 Free PMC article.
TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.
Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F. Paget C, et al. Among authors: speak ao. PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar. PLoS Biol. 2019. PMID: 30822302 Free PMC article.
Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.
Porubsky S, Speak AO, Salio M, Jennemann R, Bonrouhi M, Zafarulla R, Singh Y, Dyson J, Luckow B, Lehuen A, Malle E, Müthing J, Platt FM, Cerundolo V, Gröne HJ. Porubsky S, et al. Among authors: speak ao. J Immunol. 2012 Sep 15;189(6):3007-17. doi: 10.4049/jimmunol.1201483. Epub 2012 Aug 8. J Immunol. 2012. PMID: 22875802 Free PMC article.
52 results