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Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3.
Abel EV, Basile KJ, Kugel CH 3rd, Witkiewicz AK, Le K, Amaravadi RK, Karakousis GC, Xu X, Xu W, Schuchter LM, Lee JB, Ertel A, Fortina P, Aplin AE. Abel EV, et al. Among authors: witkiewicz ak. J Clin Invest. 2013 May;123(5):2155-68. doi: 10.1172/JCI65780. Epub 2013 Apr 1. J Clin Invest. 2013. PMID: 23543055 Free PMC article.
Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.
Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP. Whitaker-Menezes D, et al. Among authors: witkiewicz ak. Cell Cycle. 2011 Jun 1;10(11):1772-83. doi: 10.4161/cc.10.11.15659. Epub 2011 Jun 1. Cell Cycle. 2011. PMID: 21558814 Free PMC article.
RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.
McClendon AK, Dean JL, Ertel A, Fu Z, Rivadeneira DB, Reed CA, Bourgo RJ, Witkiewicz A, Addya S, Mayhew CN, Grimes HL, Fortina P, Knudsen ES. McClendon AK, et al. Among authors: witkiewicz a. Gastroenterology. 2011 Oct;141(4):1439-50. doi: 10.1053/j.gastro.2011.06.046. Epub 2011 Jun 24. Gastroenterology. 2011. PMID: 21704587 Free PMC article.
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.
Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Pavlides S, Tsirigos A, Ertel A, Pestell RG, Broda P, Minetti C, Lisanti MP, Sotgia F. Whitaker-Menezes D, et al. Among authors: witkiewicz ak. Cell Cycle. 2011 Dec 1;10(23):4047-64. doi: 10.4161/cc.10.23.18151. Epub 2011 Dec 1. Cell Cycle. 2011. PMID: 22134189 Free PMC article.
176 results