Saarma M - Search Results

1

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.

Bäck S, Peränen J, Galli E, Pulkkila P, Lonka-Nevalaita L, Tamminen T, Voutilainen MH, Raasmaja A, Saarma M, Männistö PT, Tuominen RK. Bäck S, et al. Among authors: saarma m. Brain Behav. 2013 Mar;3(2):75-88. doi: 10.1002/brb3.117. Epub 2013 Jan 14. Brain Behav. 2013. PMID: 23532969 Free PMC article.

2

Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.

Rossi J, Luukko K, Poteryaev D, Laurikainen A, Sun YF, Laakso T, Eerikäinen S, Tuominen R, Lakso M, Rauvala H, Arumäe U, Pasternack M, Saarma M, Airaksinen MS. Rossi J, et al. Among authors: saarma m. Neuron. 1999 Feb;22(2):243-52. doi: 10.1016/s0896-6273(00)81086-7. Neuron. 1999. PMID: 10069331 Free article.

3

Effects of repeated morphine on locomotion, place preference and dopamine in heterozygous glial cell line-derived neurotrophic factor knockout mice.

Airavaara M, Tuomainen H, Piepponen TP, Saarma M, Ahtee L. Airavaara M, et al. Among authors: saarma m. Genes Brain Behav. 2007 Apr;6(3):287-98. doi: 10.1111/j.1601-183X.2006.00260.x. Epub 2006 Jul 27. Genes Brain Behav. 2007. PMID: 16879618 Free article.

4

Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra.

Mijatovic J, Airavaara M, Planken A, Auvinen P, Raasmaja A, Piepponen TP, Costantini F, Ahtee L, Saarma M. Mijatovic J, et al. Among authors: saarma m. J Neurosci. 2007 May 2;27(18):4799-809. doi: 10.1523/JNEUROSCI.5647-06.2007. J Neurosci. 2007. PMID: 17475787 Free PMC article.

5

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M. Lindholm P, et al. Among authors: saarma m. Nature. 2007 Jul 5;448(7149):73-7. doi: 10.1038/nature05957. Nature. 2007. PMID: 17611540

6

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.

Lindholm P, Peränen J, Andressoo JO, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Saarma M. Lindholm P, et al. Among authors: saarma m. Mol Cell Neurosci. 2008 Nov;39(3):356-71. doi: 10.1016/j.mcn.2008.07.016. Epub 2008 Jul 30. Mol Cell Neurosci. 2008. PMID: 18718866

7

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.

Palgi M, Lindström R, Peränen J, Piepponen TP, Saarma M, Heino TI. Palgi M, et al. Among authors: saarma m. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2429-34. doi: 10.1073/pnas.0810996106. Epub 2009 Jan 22. Proc Natl Acad Sci U S A. 2009. PMID: 19164766 Free PMC article.

8

The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.

Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A. Parkash V, et al. Among authors: saarma m. Protein Eng Des Sel. 2009 Apr;22(4):233-41. doi: 10.1093/protein/gzn080. Epub 2009 Mar 3. Protein Eng Des Sel. 2009. PMID: 19258449

9

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats.

Airavaara M, Shen H, Kuo CC, Peränen J, Saarma M, Hoffer B, Wang Y. Airavaara M, et al. Among authors: saarma m. J Comp Neurol. 2009 Jul 1;515(1):116-24. doi: 10.1002/cne.22039. J Comp Neurol. 2009. PMID: 19399876 Free PMC article.

10

Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons.

Piltonen M, Bespalov MM, Ervasti D, Matilainen T, Sidorova YA, Rauvala H, Saarma M, Männistö PT. Piltonen M, et al. Among authors: saarma m. Exp Neurol. 2009 Oct;219(2):499-506. doi: 10.1016/j.expneurol.2009.07.002. Epub 2009 Jul 15. Exp Neurol. 2009. PMID: 19615368

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