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Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.
Siddiq A, Ayoub IA, Chavez JC, Aminova L, Shah S, LaManna JC, Patton SM, Connor JR, Cherny RA, Volitakis I, Bush AI, Langsetmo I, Seeley T, Gunzler V, Ratan RR. Siddiq A, et al. Among authors: ratan rr. J Biol Chem. 2005 Dec 16;280(50):41732-43. doi: 10.1074/jbc.M504963200. Epub 2005 Oct 13. J Biol Chem. 2005. PMID: 16227210 Free PMC article.
Harnessing hypoxic adaptation to prevent, treat, and repair stroke.
Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J. Ratan RR, et al. J Mol Med (Berl). 2007 Dec;85(12):1331-8. doi: 10.1007/s00109-007-0283-1. Epub 2007 Nov 28. J Mol Med (Berl). 2007. PMID: 18043901 Free PMC article. Review.
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. Ratan RR, et al. Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033. Ann N Y Acad Sci. 2008. PMID: 19076458 Free PMC article.
172 results