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The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release.
Asquith DL, Ballantine LE, Nijjar JS, Makdasy MK, Patel S, Wright PB, Reilly JH, Kerr S, Kurowska-Stolarska M, Gracie JA, McInnes IB. Asquith DL, et al. Among authors: makdasy mk. Ann Rheum Dis. 2013 Dec;72(12):2024-31. doi: 10.1136/annrheumdis-2012-202872. Epub 2013 Feb 23. Ann Rheum Dis. 2013. PMID: 23434566 Free article.