Luo X - Search Results

1

Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.

Huang G, Chen H, Dong Y, Luo X, Yu H, Moore Z, Bey EA, Boothman DA, Gao J. Huang G, et al. Among authors: luo x. Theranostics. 2013;3(2):116-26. doi: 10.7150/thno.5411. Epub 2013 Feb 1. Theranostics. 2013. PMID: 23423156 Free PMC article.

2

Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.

Ma X, Huang X, Huang G, Li L, Wang Y, Luo X, Boothman DA, Gao J. Ma X, et al. Among authors: luo x. Adv Healthc Mater. 2014 Aug;3(8):1210-6. doi: 10.1002/adhm.201300590. Epub 2014 Feb 14. Adv Healthc Mater. 2014. PMID: 24532286 Free PMC article.

3

Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.

Chakrabarti G, Silvers MA, Ilcheva M, Liu Y, Moore ZR, Luo X, Gao J, Anderson G, Liu L, Sarode V, Gerber DE, Burma S, DeBerardinis RJ, Gerson SL, Boothman DA. Chakrabarti G, et al. Among authors: luo x. Sci Rep. 2015 Nov 25;5:17066. doi: 10.1038/srep17066. Sci Rep. 2015. PMID: 26602448 Free PMC article.

4

The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.

Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME. Silvers MA, et al. Among authors: luo x. J Biol Chem. 2017 Nov 3;292(44):18203-18216. doi: 10.1074/jbc.M117.813923. Epub 2017 Sep 15. J Biol Chem. 2017. PMID: 28916726 Free PMC article.

5

NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone.

Moore Z, Chakrabarti G, Luo X, Ali A, Hu Z, Fattah FJ, Vemireddy R, DeBerardinis RJ, Brekken RA, Boothman DA. Moore Z, et al. Among authors: luo x. Cell Death Dis. 2015 Jan 15;6(1):e1599. doi: 10.1038/cddis.2014.564. Cell Death Dis. 2015. PMID: 25590809 Free PMC article.

6

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.

Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA. Chakrabarti G, et al. Among authors: luo x. Cancer Metab. 2015 Oct 12;3:12. doi: 10.1186/s40170-015-0137-1. eCollection 2015. Cancer Metab. 2015. PMID: 26462257 Free PMC article.

7

ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence.

Luo X, Suzuki M, Ghandhi SA, Amundson SA, Boothman DA. Luo X, et al. PLoS One. 2014 Jun 17;9(6):e99983. doi: 10.1371/journal.pone.0099983. eCollection 2014. PLoS One. 2014. PMID: 24937130 Free PMC article.

8

ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability.

Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA. Goetz EM, et al. Among authors: luo x. Oncogene. 2011 Sep 1;30(35):3745-54. doi: 10.1038/onc.2011.92. Epub 2011 Apr 4. Oncogene. 2011. PMID: 21460853 Free PMC article.

9

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway.

Deng Q, Yu X, Xiao L, Hu Z, Luo X, Tao Y, Yang L, Liu X, Chen H, Ding Z, Feng T, Tang Y, Weng X, Gao J, Yi W, Bode AM, Dong Z, Liu J, Cao Y. Deng Q, et al. Among authors: luo x. Cell Death Dis. 2013 Sep 19;4(9):e804. doi: 10.1038/cddis.2013.324. Cell Death Dis. 2013. PMID: 24052072 Free PMC article.

10

Low dose IR-induced IGF-1-sCLU expression: a p53-repressed expression cascade that interferes with TGFβ1 signaling to confer a pro-survival bystander effect.

Klokov D, Leskov K, Araki S, Zou Y, Goetz EM, Luo X, Willson D, Boothman DA. Klokov D, et al. Among authors: luo x. Oncogene. 2013 Jan 24;32(4):479-90. doi: 10.1038/onc.2012.64. Epub 2012 Mar 5. Oncogene. 2013. PMID: 22391565 Free PMC article.

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