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223 results

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Page 1
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).
Takeuchi CS, Kim BG, Blazey CM, Ma S, Johnson HW, Anand NK, Arcalas A, Baik TG, Buhr CA, Cannoy J, Epshteyn S, Joshi A, Lara K, Lee MS, Wang L, Leahy JW, Nuss JM, Aay N, Aoyama R, Foster P, Lee J, Lehoux I, Munagala N, Plonowski A, Rajan S, Woolfrey J, Yamaguchi K, Lamb P, Miller N. Takeuchi CS, et al. Among authors: anand nk. J Med Chem. 2013 Mar 28;56(6):2218-34. doi: 10.1021/jm3007933. Epub 2013 Mar 7. J Med Chem. 2013. PMID: 23394126
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors.
Bussenius J, Anand NK, Blazey CM, Bowles OJ, Bannen LC, Chan DS, Chen B, Co EW, Costanzo S, DeFina SC, Dubenko L, Engst S, Franzini M, Huang P, Jammalamadaka V, Khoury RG, Kim MH, Klein RR, Laird D, Le DT, Mac MB, Matthews DJ, Markby D, Miller N, Nuss JM, Parks JJ, Tsang TH, Tsuhako AL, Wang Y, Xu W, Rice KD. Bussenius J, et al. Among authors: anand nk. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2283-6. doi: 10.1016/j.bmcl.2012.01.105. Epub 2012 Feb 2. Bioorg Med Chem Lett. 2012. PMID: 22342124
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors.
Rice KD, Kim MH, Bussenius J, Anand NK, Blazey CM, Bowles OJ, Canne-Bannen L, Chan DS, Chen B, Co EW, Costanzo S, DeFina SC, Dubenko L, Engst S, Franzini M, Huang P, Jammalamadaka V, Khoury RG, Klein RR, Laird AD, Le DT, Mac MB, Matthews DJ, Markby D, Miller N, Nuss JM, Parks JJ, Tsang TH, Tsuhako AL, Wang Y, Xu W. Rice KD, et al. Among authors: anand nk. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2693-7. doi: 10.1016/j.bmcl.2012.03.011. Epub 2012 Mar 10. Bioorg Med Chem Lett. 2012. PMID: 22450127
Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.
Bussenius J, Blazey CM, Aay N, Anand NK, Arcalas A, Baik T, Bowles OJ, Buhr CA, Costanzo S, Curtis JK, DeFina SC, Dubenko L, Heuer TS, Huang P, Jaeger C, Joshi A, Kennedy AR, Kim AI, Lara K, Lee J, Li J, Lougheed JC, Ma S, Malek S, Manalo JC, Martini JF, McGrath G, Nicoll M, Nuss JM, Pack M, Peto CJ, Tsang TH, Wang L, Womble SW, Yakes M, Zhang W, Rice KD. Bussenius J, et al. Among authors: anand nk. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5396-404. doi: 10.1016/j.bmcl.2012.07.052. Epub 2012 Jul 21. Bioorg Med Chem Lett. 2012. PMID: 22877636
Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973).
Rice KD, Aay N, Anand NK, Blazey CM, Bowles OJ, Bussenius J, Costanzo S, Curtis JK, Defina SC, Dubenko L, Engst S, Joshi AA, Kennedy AR, Kim AI, Koltun ES, Lougheed JC, Manalo JC, Martini JF, Nuss JM, Peto CJ, Tsang TH, Yu P, Johnston S. Rice KD, et al. Among authors: anand nk. ACS Med Chem Lett. 2012 Apr 9;3(5):416-21. doi: 10.1021/ml300049d. eCollection 2012 May 10. ACS Med Chem Lett. 2012. PMID: 24900486 Free PMC article.
The minimally invasive spinal deformity surgery algorithm: a reproducible rational framework for decision making in minimally invasive spinal deformity surgery.
Mummaneni PV, Shaffrey CI, Lenke LG, Park P, Wang MY, La Marca F, Smith JS, Mundis GM Jr, Okonkwo DO, Moal B, Fessler RG, Anand N, Uribe JS, Kanter AS, Akbarnia B, Fu KM; Minimally Invasive Surgery Section of the International Spine Study Group. Mummaneni PV, et al. Neurosurg Focus. 2014 May;36(5):E6. doi: 10.3171/2014.3.FOCUS1413. Neurosurg Focus. 2014. PMID: 24785488
Comparison of two minimally invasive surgery strategies to treat adult spinal deformity.
Park P, Wang MY, Lafage V, Nguyen S, Ziewacz J, Okonkwo DO, Uribe JS, Eastlack RK, Anand N, Haque R, Fessler RG, Kanter AS, Deviren V, La Marca F, Smith JS, Shaffrey CI, Mundis GM Jr, Mummaneni PV; International Spine Study Group. Park P, et al. J Neurosurg Spine. 2015 Apr;22(4):374-80. doi: 10.3171/2014.9.SPINE131004. Epub 2015 Jan 30. J Neurosurg Spine. 2015. PMID: 25635632
Comparison of radiographic results after minimally invasive, hybrid, and open surgery for adult spinal deformity: a multicenter study of 184 patients.
Haque RM, Mundis GM Jr, Ahmed Y, El Ahmadieh TY, Wang MY, Mummaneni PV, Uribe JS, Okonkwo DO, Eastlack RK, Anand N, Kanter AS, La Marca F, Akbarnia BA, Park P, Lafage V, Terran JS, Shaffrey CI, Klineberg E, Deviren V, Fessler RG; International Spine Study Group. Haque RM, et al. Neurosurg Focus. 2014 May;36(5):E13. doi: 10.3171/2014.3.FOCUS1424. Neurosurg Focus. 2014. PMID: 24785478
Complications in adult spinal deformity surgery: an analysis of minimally invasive, hybrid, and open surgical techniques.
Uribe JS, Deukmedjian AR, Mummaneni PV, Fu KM, Mundis GM Jr, Okonkwo DO, Kanter AS, Eastlack R, Wang MY, Anand N, Fessler RG, La Marca F, Park P, Lafage V, Deviren V, Bess S, Shaffrey CI; International Spine Study Group. Uribe JS, et al. Neurosurg Focus. 2014 May;36(5):E15. doi: 10.3171/2014.3.FOCUS13534. Neurosurg Focus. 2014. PMID: 24785480
Does Minimally Invasive Percutaneous Posterior Instrumentation Reduce Risk of Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery? A Propensity-Matched Cohort Analysis.
Mummaneni PV, Park P, Fu KM, Wang MY, Nguyen S, Lafage V, Uribe JS, Ziewacz J, Terran J, Okonkwo DO, Anand N, Fessler R, Kanter AS, LaMarca F, Deviren V, Bess RS, Schwab FJ, Smith JS, Akbarnia BA, Mundis GM Jr, Shaffrey CI; International Spine Study Group. Mummaneni PV, et al. Neurosurgery. 2016 Jan;78(1):101-8. doi: 10.1227/NEU.0000000000001002. Neurosurgery. 2016. PMID: 26348014
223 results