The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes.
McLeod SJ, Shum AJ, Lee RL, Takei F, Gold MR.
McLeod SJ, et al.
J Biol Chem. 2004 Mar 26;279(13):12009-19. doi: 10.1074/jbc.M313098200. Epub 2003 Dec 29.
J Biol Chem. 2004.
PMID: 14701796
Free article.
We have previously shown that anti-Ig antibodies, the chemokine stromal cell-derived factor-1 (SDF-1; CXCL12), and phorbol esters activate the Rap1 and Rap2 GTPases in B cells and that Rap activation is essential for SDF-1-induced B cell migration (McLeod, S. J., Li …
We have previously shown that anti-Ig antibodies, the chemokine stromal cell-derived factor-1 (SDF-1; CXCL12), and phorbol esters activate t …