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Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.
Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, Sonenberg N, Roberge M. Fonseca BD, et al. Among authors: forestieri r. J Biol Chem. 2012 May 18;287(21):17530-17545. doi: 10.1074/jbc.M112.359638. Epub 2012 Apr 2. J Biol Chem. 2012. PMID: 22474287 Free PMC article.
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1.
Persaud R, Li SC, Chao JD, Forestieri R, Donohue E, Balgi AD, Zheng X, Chao JT, Yashiroda Y, Yoshimura M, Loewen CJR, Gingras AC, Boone C, Av-Gay Y, Roberge M, Andersen RJ. Persaud R, et al. Among authors: forestieri r. Cell Chem Biol. 2022 May 19;29(5):870-882.e11. doi: 10.1016/j.chembiol.2021.07.017. Epub 2021 Sep 13. Cell Chem Biol. 2022. PMID: 34520745 Free article.