Barton HA - Search Results

1

Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.

Barton HA, Lai Y, Goosen TC, Jones HM, El-Kattan AF, Gosset JR, Lin J, Varma MV. Barton HA, et al. Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):459-72. doi: 10.1517/17425255.2013.759210. Epub 2013 Jan 21. Expert Opin Drug Metab Toxicol. 2013. PMID: 23331046 Review.

2

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.

Bi YA, Kimoto E, Sevidal S, Jones HM, Barton HA, Kempshall S, Whalen KM, Zhang H, Ji C, Fenner KS, El-Kattan AF, Lai Y. Bi YA, et al. Among authors: barton ha. Drug Metab Dispos. 2012 Jun;40(6):1085-92. doi: 10.1124/dmd.111.043489. Epub 2012 Mar 1. Drug Metab Dispos. 2012. PMID: 22381335 Review.

3

Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.

Li R, Barton HA, Varma MV. Li R, et al. Among authors: barton ha. Clin Pharmacokinet. 2014 Aug;53(8):659-78. doi: 10.1007/s40262-014-0156-z. Clin Pharmacokinet. 2014. PMID: 25056496 Review.

4

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.

Fenner KS, Jones HM, Ullah M, Kempshall S, Dickins M, Lai Y, Morgan P, Barton HA. Fenner KS, et al. Among authors: barton ha. Xenobiotica. 2012 Jan;42(1):28-45. doi: 10.3109/00498254.2011.626464. Epub 2011 Nov 11. Xenobiotica. 2012. PMID: 22077101 Review.

5

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS. Jones HM, et al. Among authors: barton ha. Drug Metab Dispos. 2012 May;40(5):1007-17. doi: 10.1124/dmd.111.042994. Epub 2012 Feb 16. Drug Metab Dispos. 2012. PMID: 22344703

6

A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.

Jones HM, Zhang Z, Jasper P, Luo H, Avery LB, King LE, Neubert H, Barton HA, Betts AM, Webster R. Jones HM, et al. Among authors: barton ha. CPT Pharmacometrics Syst Pharmacol. 2019 Oct;8(10):738-747. doi: 10.1002/psp4.12461. Epub 2019 Sep 23. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31464379 Free PMC article.

7

Physiologically based pharmacokinetic prediction of telmisartan in human.

Li R, Ghosh A, Maurer TS, Kimoto E, Barton HA. Li R, et al. Among authors: barton ha. Drug Metab Dispos. 2014 Oct;42(10):1646-55. doi: 10.1124/dmd.114.058461. Epub 2014 Aug 4. Drug Metab Dispos. 2014. PMID: 25092714

8

A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling.

Li R, Barton HA, Yates PD, Ghosh A, Wolford AC, Riccardi KA, Maurer TS. Li R, et al. Among authors: barton ha. J Pharmacokinet Pharmacodyn. 2014 Jun;41(3):197-209. doi: 10.1007/s10928-014-9357-1. Epub 2014 Apr 10. J Pharmacokinet Pharmacodyn. 2014. PMID: 24718648

9

Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds.

Li R, Maurer TS, Sweeney K, Barton HA. Li R, et al. Among authors: barton ha. AAPS J. 2016 May;18(3):746-56. doi: 10.1208/s12248-016-9895-0. Epub 2016 Mar 7. AAPS J. 2016. PMID: 26951483 Free PMC article.

10

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.

Shah F, Leung L, Barton HA, Will Y, Rodrigues AD, Greene N, Aleo MD. Shah F, et al. Among authors: barton ha. Toxicol Sci. 2015 Oct;147(2):500-14. doi: 10.1093/toxsci/kfv152. Epub 2015 Jul 23. Toxicol Sci. 2015. PMID: 26206150

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