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p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth.
Tkach M, Rosemblit C, Rivas MA, Proietti CJ, Díaz Flaqué MC, Mercogliano MF, Beguelin W, Maronna E, Guzmán P, Gercovich FG, Deza EG, Elizalde PV, Schillaci R. Tkach M, et al. Among authors: proietti cj. Endocr Relat Cancer. 2013 Mar 22;20(2):197-212. doi: 10.1530/ERC-12-0194. Print 2013 Apr. Endocr Relat Cancer. 2013. PMID: 23329648 Free article.
Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.
Puricelli L, Proietti CJ, Labriola L, Salatino M, Balañá ME, Aguirre Ghiso J, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffé E, Elizalde PV. Puricelli L, et al. Among authors: proietti cj. Int J Cancer. 2002 Aug 20;100(6):642-53. doi: 10.1002/ijc.10533. Int J Cancer. 2002. PMID: 12209601
Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.
Labriola L, Salatino M, Proietti CJ, Pecci A, Coso OA, Kornblihtt AR, Charreau EH, Elizalde PV. Labriola L, et al. Among authors: proietti cj. Mol Cell Biol. 2003 Feb;23(3):1095-111. doi: 10.1128/MCB.23.3.1095-1111.2003. Mol Cell Biol. 2003. PMID: 12529413 Free PMC article.
Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity.
Salatino M, Schillaci R, Proietti CJ, Carnevale R, Frahm I, Molinolo AA, Iribarren A, Charreau EH, Elizalde PV. Salatino M, et al. Among authors: proietti cj. Oncogene. 2004 Jul 1;23(30):5161-74. doi: 10.1038/sj.onc.1207659. Oncogene. 2004. PMID: 15122317
Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathway.
Schillaci R, Salatino M, Cassataro J, Proietti CJ, Giambartolomei GH, Rivas MA, Carnevale RP, Charreau EH, Elizalde PV. Schillaci R, et al. Among authors: proietti cj. J Immunol. 2006 Mar 15;176(6):3426-37. doi: 10.4049/jimmunol.176.6.3426. J Immunol. 2006. PMID: 16517711
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.
Salatino M, Beguelin W, Peters MG, Carnevale R, Proietti CJ, Galigniana MD, Vedoy CG, Schillaci R, Charreau EH, Sogayar MC, Elizalde PV. Salatino M, et al. Among authors: proietti cj. Oncogene. 2006 Dec 14;25(59):7723-39. doi: 10.1038/sj.onc.1209757. Epub 2006 Jun 26. Oncogene. 2006. PMID: 16799639
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.
Carnevale RP, Proietti CJ, Salatino M, Urtreger A, Peluffo G, Edwards DP, Boonyaratanakornkit V, Charreau EH, Bal de Kier Joffé E, Schillaci R, Elizalde PV. Carnevale RP, et al. Among authors: proietti cj. Mol Endocrinol. 2007 Jun;21(6):1335-58. doi: 10.1210/me.2006-0304. Epub 2007 Apr 17. Mol Endocrinol. 2007. PMID: 17440047
44 results