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The Shc locus regulates insulin signaling and adiposity in mammals.
Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. Tomilov AA, et al. Aging Cell. 2011 Feb;10(1):55-65. doi: 10.1111/j.1474-9726.2010.00641.x. Epub 2010 Nov 15. Aging Cell. 2011. PMID: 21040401 Free PMC article.
Hepatic Src homology phosphatase 2 regulates energy balance in mice.
Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Nagata N, et al. Endocrinology. 2012 Jul;153(7):3158-69. doi: 10.1210/en.2012-1406. Epub 2012 May 22. Endocrinology. 2012. PMID: 22619361 Free PMC article.
The influence of Shc proteins on life span in mice.
Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. Ramsey JJ, et al. Among authors: tomilov aa. J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1177-85. doi: 10.1093/gerona/glt198. Epub 2013 Dec 14. J Gerontol A Biol Sci Med Sci. 2014. PMID: 24336818 Free PMC article.
Shc depletion stimulates brown fat activity in vivo and in vitro.
Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. Tomilov A, et al. Aging Cell. 2014 Dec;13(6):1049-58. doi: 10.1111/acel.12267. Epub 2014 Sep 26. Aging Cell. 2014. PMID: 25257068 Free PMC article.
p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria.
Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. Tomilov A, et al. J Biol Chem. 2016 Jun 10;291(24):12575-12585. doi: 10.1074/jbc.M115.695577. Epub 2016 Apr 8. J Biol Chem. 2016. PMID: 27059956 Free PMC article.
50 results