Widzowski DV - Search Results

1

Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists.

Urbanek RA, Xiong H, Wu Y, Blackwell W, Steelman G, Rosamond J, Wesolowski SS, Campbell JB, Zhang M, Brockel B, Widzowski DV. Urbanek RA, et al. Among authors: widzowski dv. Bioorg Med Chem Lett. 2013 Jan 15;23(2):543-7. doi: 10.1016/j.bmcl.2012.11.023. Epub 2012 Nov 28. Bioorg Med Chem Lett. 2013. PMID: 23237836

2

Preclinical pharmacology and pharmacokinetics of AZD3783, a selective 5-hydroxytryptamine 1B receptor antagonist.

Zhang M, Zhou D, Wang Y, Maier DL, Widzowski DV, Sobotka-Briner CD, Brockel BJ, Potts WM, Shenvi AB, Bernstein PR, Pierson ME. Zhang M, et al. Among authors: widzowski dv. J Pharmacol Exp Ther. 2011 Nov;339(2):567-78. doi: 10.1124/jpet.110.174433. Epub 2011 Aug 8. J Pharmacol Exp Ther. 2011. PMID: 21825000 Clinical Trial.

3

Quantification of the interrelationships of receptor pharmacologies within a tricyclic privileged structural scaffold through application of modified forward selection.

Wood MW, Wesolowski SS, Widzowski DV, Cross AJ. Wood MW, et al. Among authors: widzowski dv. Neuropharmacology. 2014 Feb;77:475-80. Neuropharmacology. 2014. PMID: 24490229 Free article.

4

Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268.

Zysk JR, Widzowski D, Sygowski LA, Knappenberger KS, Spear N, Elmore CS, Dorff P, Liu H, Doherty J, Chhajlani V. Zysk JR, et al. Synapse. 2011 Jan;65(1):64-8. doi: 10.1002/syn.20817. Synapse. 2011. PMID: 20506301

5

D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]-MNPA, [3H]-(+)-PHNO, and [3H]-raclopride.

Peng T, Zysk J, Dorff P, Elmore CS, Ström P, Malmquist J, Ding M, Tuke D, Werkheiser J, Widzowski D, Mrzljak L, Maier D. Peng T, et al. Synapse. 2010 Aug;64(8):624-33. doi: 10.1002/syn.20771. Synapse. 2010. PMID: 20340171

6

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS. Sydserff S, et al. Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. Epub 2009 Jul 16. Biochem Pharmacol. 2009. PMID: 19615981

7

Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models.

Cross AJ, Widzowski D, Maciag C, Zacco A, Hudzik T, Liu J, Nyberg S, Wood MW. Cross AJ, et al. Br J Pharmacol. 2016 Jan;173(1):155-66. doi: 10.1111/bph.13346. Epub 2015 Dec 1. Br J Pharmacol. 2016. PMID: 26436896 Free PMC article.

8

Broad analgesic activity of a novel, selective M1 agonist.

Wood MW, Martino G, Coupal M, Lindberg M, Schroeder P, Santhakumar V, Valiquette M, Sandin J, Widzowski D, Laird J. Wood MW, et al. Neuropharmacology. 2017 Sep 1;123:233-241. doi: 10.1016/j.neuropharm.2017.06.010. Epub 2017 Jun 13. Neuropharmacology. 2017. PMID: 28623171 Free article.

9

Long-term functional end points following middle cerebral artery occlusion in the rat.

Hudzik TJ, Borrelli A, Bialobok P, Widzowski D, Sydserff S, Howell A, Gendron P, Corbett D, Miller J, Palmer GC. Hudzik TJ, et al. Pharmacol Biochem Behav. 2000 Mar;65(3):553-62. doi: 10.1016/s0091-3057(99)00243-9. Pharmacol Biochem Behav. 2000. PMID: 10683498

10

Low affinity use-dependent NMDA receptor antagonists show promise for clinical development.

Palmer GC, Widzowski D. Palmer GC, et al. Amino Acids. 2000;19(1):151-5. doi: 10.1007/s007260070043. Amino Acids. 2000. PMID: 11026483 Review.

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