Aonuma M - Search Results

1

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.

Setoguchi M, Iimura S, Sugimoto Y, Yoneda Y, Chiba J, Watanabe T, Muro F, Iigo Y, Takayama G, Yokoyama M, Taira T, Aonuma M, Takashi T, Nakayama A, Machinaga N. Setoguchi M, et al. Among authors: aonuma m. Bioorg Med Chem. 2013 Jan 1;21(1):42-61. doi: 10.1016/j.bmc.2012.11.003. Epub 2012 Nov 10. Bioorg Med Chem. 2013. PMID: 23218775

2

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.

Setoguchi M, Iimura S, Sugimoto Y, Yoneda Y, Chiba J, Watanabe T, Muro F, Iigo Y, Takayama G, Yokoyama M, Taira T, Aonuma M, Takashi T, Nakayama A, Machinaga N. Setoguchi M, et al. Among authors: aonuma m. Bioorg Med Chem. 2012 Feb 1;20(3):1201-12. doi: 10.1016/j.bmc.2011.12.045. Epub 2011 Dec 30. Bioorg Med Chem. 2012. PMID: 22261021

3

Improvement of pulmonary function by oral treatment with a VLA-4 antagonist in a mouse asthmatic model.

Takayama G, Matsumoto K, Taira T, Aonuma M, Yokoyama M, Iigo Y, Takashi T. Takayama G, et al. Among authors: aonuma m. J Pharmacol Sci. 2013;121(2):172-5. doi: 10.1254/jphs.12198sc. J Pharmacol Sci. 2013. PMID: 23419271 Free article.

4

Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors.

Terashima H, Aonuma M, Tsuchida H, Sugimoto K, Yokoyama M, Kato M. Terashima H, et al. Among authors: aonuma m. Pulm Pharmacol Ther. 2019 Feb;54:31-38. doi: 10.1016/j.pupt.2018.11.005. Epub 2018 Nov 15. Pulm Pharmacol Ther. 2019. PMID: 30448291 Free article.

5

A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo.

Mitsui I, Kumazawa E, Hirota Y, Aonuma M, Sugimori M, Ohsuki S, Uoto K, Ejima A, Terasawa H, Sato K. Mitsui I, et al. Among authors: aonuma m. Jpn J Cancer Res. 1995 Aug;86(8):776-82. doi: 10.1111/j.1349-7006.1995.tb02468.x. Jpn J Cancer Res. 1995. PMID: 7559102 Free PMC article.

6

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice.

Kawato Y, Furuta T, Aonuma M, Yasuoka M, Yokokura T, Matsumoto K. Kawato Y, et al. Among authors: aonuma m. Cancer Chemother Pharmacol. 1991;28(3):192-8. doi: 10.1007/BF00685508. Cancer Chemother Pharmacol. 1991. PMID: 1855276

7

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K. Kawato Y, et al. Among authors: aonuma m. Cancer Res. 1991 Aug 15;51(16):4187-91. Cancer Res. 1991. PMID: 1651156

8

Different antitumor activities of anti-bFGF neutralizing antibodies: heparin-binding domain provides an inefficient epitope for neutralization in vivo.

Aonuma M, Yoshitake Y, Nishikawa K, Tanaka NG. Aonuma M, et al. Anticancer Res. 1999 Sep-Oct;19(5B):4039-44. Anticancer Res. 1999. PMID: 10628351

9

Vascular endothelial growth factor overproduced by tumour cells acts predominantly as a potent angiogenic factor contributing to malignant progression.

Aonuma M, Saeki Y, Akimoto T, Nakayama Y, Hattori C, Yoshitake Y, Nishikawa K, Shibuya M, Tanaka NG. Aonuma M, et al. Int J Exp Pathol. 1999 Oct;80(5):271-81. doi: 10.1046/j.1365-2613.1999.00122.x. Int J Exp Pathol. 1999. PMID: 10607018 Free PMC article.

10

In vivo malignant phenotype of hst-1-transfected cells regulated by paracrine endothelial cell growth stimulation by HST-1.

Aonuma M, Murakami K, Hirotani K, Horiuchi T, Sakamoto H, Terada M, Tanaka NG. Aonuma M, et al. Angiogenesis. 1998;2(2):143-52. doi: 10.1023/a:1009288405970. Angiogenesis. 1998. PMID: 14517470

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