Phan K - Search Results

1

Limits of ligand selectivity from docking to models: in silico screening for A(1) adenosine receptor antagonists.

Kolb P, Phan K, Gao ZG, Marko AC, Sali A, Jacobson KA. Kolb P, et al. Among authors: phan k. PLoS One. 2012;7(11):e49910. doi: 10.1371/journal.pone.0049910. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185482 Free PMC article.

2

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA. Deflorian F, et al. Among authors: phan k. J Med Chem. 2012 Jan 12;55(1):538-52. doi: 10.1021/jm201461q. Epub 2011 Dec 12. J Med Chem. 2012. PMID: 22104008 Free PMC article.

3

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Tosh DK, et al. Among authors: phan k. J Med Chem. 2012 May 10;55(9):4297-308. doi: 10.1021/jm300095s. Epub 2012 Apr 30. J Med Chem. 2012. PMID: 22486652 Free PMC article.

4

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

Tosh DK, Deflorian F, Phan K, Gao ZG, Wan TC, Gizewski E, Auchampach JA, Jacobson KA. Tosh DK, et al. Among authors: phan k. J Med Chem. 2012 May 24;55(10):4847-60. doi: 10.1021/jm300396n. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559880 Free PMC article.

5

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Tosh DK, Paoletta S, Deflorian F, Phan K, Moss SM, Gao ZG, Jiang X, Jacobson KA. Tosh DK, et al. Among authors: phan k. J Med Chem. 2012 Sep 27;55(18):8075-90. doi: 10.1021/jm300965a. Epub 2012 Sep 10. J Med Chem. 2012. PMID: 22921089 Free PMC article.

6

Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.

Jayasekara PS, Phan K, Tosh DK, Kumar TS, Moss SM, Zhang G, Barchi JJ Jr, Gao ZG, Jacobson KA. Jayasekara PS, et al. Among authors: phan k. Purinergic Signal. 2013 Jun;9(2):183-98. doi: 10.1007/s11302-012-9338-z. Epub 2012 Nov 20. Purinergic Signal. 2013. PMID: 23179047 Free PMC article.

7

Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.

Dix AV, Moss SM, Phan K, Hoppe T, Paoletta S, Kozma E, Gao ZG, Durell SR, Jacobson KA, Appella DH. Dix AV, et al. Among authors: phan k. J Am Chem Soc. 2014 Sep 3;136(35):12296-303. doi: 10.1021/ja504288s. Epub 2014 Aug 25. J Am Chem Soc. 2014. PMID: 25116377 Free PMC article.

8

Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A₃ Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary.

Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Lee Y, et al. Among authors: phan k. J Med Chem. 2021 Sep 9;64(17):12525-12536. doi: 10.1021/acs.jmedchem.1c00239. Epub 2021 Aug 26. J Med Chem. 2021. PMID: 34435786 Free PMC article.

9

Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.

Kumar TS, Mishra S, Deflorian F, Yoo LS, Phan K, Kecskés M, Szabo A, Shinkre B, Gao ZG, Trenkle W, Jacobson KA. Kumar TS, et al. Among authors: phan k. Bioorg Med Chem Lett. 2011 May 1;21(9):2740-5. doi: 10.1016/j.bmcl.2010.11.082. Epub 2010 Nov 21. Bioorg Med Chem Lett. 2011. PMID: 21185184 Free PMC article.

10

Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.

Hou X, Majik MS, Kim K, Pyee Y, Lee Y, Alexander V, Chung HJ, Lee HW, Chandra G, Lee JH, Park SG, Choi WJ, Kim HO, Phan K, Gao ZG, Jacobson KA, Choi S, Lee SK, Jeong LS. Hou X, et al. Among authors: phan k. J Med Chem. 2012 Jan 12;55(1):342-56. doi: 10.1021/jm201229j. Epub 2011 Dec 28. J Med Chem. 2012. PMID: 22142423 Free PMC article.

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