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Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases.
Liu H, Irwanto A, Tian H, Fu X, Yu Y, Yu G, Low H, Chu T, Li Y, Shi B, Chen M, Sun Y, Yuan C, Lu N, You J, Bao F, Li J, Liu J, Liu H, Liu D, Yu X, Zhang L, Yang Q, Wang N, Niu G, Ma S, Zhou Y, Wang C, Chen S, Zhang X, Liu J, Zhang F. Liu H, et al. Among authors: yang q. Am J Hum Genet. 2012 Nov 2;91(5):935-41. doi: 10.1016/j.ajhg.2012.09.010. Epub 2012 Oct 25. Am J Hum Genet. 2012. PMID: 23103228 Free PMC article.
A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy.
Wang Z, Sun Y, Fu X, Yu G, Wang C, Bao F, Yue Z, Li J, Sun L, Irwanto A, Yu Y, Chen M, Mi Z, Wang H, Huai P, Li Y, Du T, Yu W, Xia Y, Xiao H, You J, Li J, Yang Q, Wang N, Shang P, Niu G, Chi X, Wang X, Cao J, Cheng X, Liu H, Liu J, Zhang F. Wang Z, et al. Among authors: yang q. Nat Commun. 2016 Dec 15;7:13760. doi: 10.1038/ncomms13760. Nat Commun. 2016. PMID: 27976721 Free PMC article.
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
Zhang F, Liu H, Chen S, Low H, Sun L, Cui Y, Chu T, Li Y, Fu X, Yu Y, Yu G, Shi B, Tian H, Liu D, Yu X, Li J, Lu N, Bao F, Yuan C, Liu J, Liu H, Zhang L, Sun Y, Chen M, Yang Q, Yang H, Yang R, Zhang L, Wang Q, Liu H, Zuo F, Zhang H, Khor CC, Hibberd ML, Yang S, Liu J, Zhang X. Zhang F, et al. Among authors: yang s, yang q, yang r, yang h. Nat Genet. 2011 Oct 23;43(12):1247-51. doi: 10.1038/ng.973. Nat Genet. 2011. PMID: 22019778
Chromosome 2p14 is linked to susceptibility to leprosy.
Yang Q, Liu H, Low HQ, Wang H, Yu Y, Fu X, Yu G, Chen M, Yan X, Chen S, Huang W, Liu J, Zhang F. Yang Q, et al. PLoS One. 2012;7(1):e29747. doi: 10.1371/journal.pone.0029747. Epub 2012 Jan 6. PLoS One. 2012. PMID: 22238647 Free PMC article.
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