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Antifungal drug discovery: something old and something new.
Butts A, Krysan DJ. Butts A, et al. Among authors: krysan dj. PLoS Pathog. 2012 Sep;8(9):e1002870. doi: 10.1371/journal.ppat.1002870. Epub 2012 Sep 6. PLoS Pathog. 2012. PMID: 22969422 Free PMC article. Review. No abstract available.
Novel Keto-Alkyl-Pyridinium Antifungal Molecules Active in Models of In Vivo Candida albicans Vascular Catheter Infection and Ex Vivo Candida auris Skin Colonization.
Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Beattie SR, et al. Among authors: krysan dj. Antimicrob Agents Chemother. 2023 May 17;67(5):e0008123. doi: 10.1128/aac.00081-23. Epub 2023 Apr 25. Antimicrob Agents Chemother. 2023. PMID: 37097144 Free PMC article.
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral commensalism.
Glazier VE, Kramara J, Ollinger T, Solis NV, Zarnowski R, Wakade RS, Kim MJ, Weigel GJ, Liang SH, Bennett RJ, Wellington M, Andes DR, Stamnes MA, Filler SG, Krysan DJ. Glazier VE, et al. Among authors: krysan dj. bioRxiv [Preprint]. 2023 Jun 17:2023.06.17.545405. doi: 10.1101/2023.06.17.545405. bioRxiv. 2023. Update in: mBio. 2023 Oct 31;14(5):e0152123. doi: 10.1128/mbio.01521-23. PMID: 37398495 Free PMC article. Updated. Preprint.
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. Miron-Ocampo A, et al. Among authors: krysan dj. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23. Epub 2023 Sep 13. Antimicrob Agents Chemother. 2023. PMID: 37702508 Free PMC article.
Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo Candida albicans vascular catheter infection and ex vivo Candida auris skin colonization.
Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Beattie SR, et al. Among authors: krysan dj. bioRxiv [Preprint]. 2023 Jan 20:2023.01.19.524835. doi: 10.1101/2023.01.19.524835. bioRxiv. 2023. Update in: Antimicrob Agents Chemother. 2023 May 17;67(5):e0008123. doi: 10.1128/aac.00081-23. PMID: 36711909 Free PMC article. Updated. Preprint.
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and oral commensalism.
Glazier VE, Kramara J, Ollinger T, Solis NV, Zarnowski R, Wakade RS, Kim M-J, Weigel GJ, Liang S-H, Bennett RJ, Wellington M, Andes DR, Stamnes MA, Filler SG, Krysan DJ. Glazier VE, et al. Among authors: krysan dj. mBio. 2023 Oct 31;14(5):e0152123. doi: 10.1128/mbio.01521-23. Epub 2023 Sep 22. mBio. 2023. PMID: 37737633 Free PMC article.
120 results