Heiser U - Search Results

1

Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.

Koch B, Buchholz M, Wermann M, Heiser U, Schilling S, Demuth HU. Koch B, et al. Among authors: heiser u. Chem Biol Drug Des. 2012 Dec;80(6):937-46. doi: 10.1111/cbdd.12046. Epub 2012 Oct 11. Chem Biol Drug Des. 2012. PMID: 22967026

2

Continuous spectrometric assays for glutaminyl cyclase activity.

Schilling S, Hoffmann T, Wermann M, Heiser U, Wasternack C, Demuth HU. Schilling S, et al. Among authors: heiser u. Anal Biochem. 2002 Apr 1;303(1):49-56. doi: 10.1006/abio.2001.5560. Anal Biochem. 2002. PMID: 11906150

3

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

Schilling S, Cynis H, von Bohlen A, Hoffmann T, Wermann M, Heiser U, Buchholz M, Zunkel K, Demuth HU. Schilling S, et al. Among authors: heiser u. Biochemistry. 2005 Oct 11;44(40):13415-24. doi: 10.1021/bi051142e. Biochemistry. 2005. PMID: 16201766

4

The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship.

Buchholz M, Heiser U, Schilling S, Niestroj AJ, Zunkel K, Demuth HU. Buchholz M, et al. Among authors: heiser u. J Med Chem. 2006 Jan 26;49(2):664-77. doi: 10.1021/jm050756e. J Med Chem. 2006. PMID: 16420052

5

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, Demuth HU. Cynis H, et al. Among authors: heiser u. Biochim Biophys Acta. 2006 Oct;1764(10):1618-25. doi: 10.1016/j.bbapap.2006.08.003. Epub 2006 Aug 16. Biochim Biophys Acta. 2006. PMID: 17005457

6

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, Demuth HU. Schilling S, et al. Among authors: heiser u. J Neurochem. 2008 Aug;106(3):1225-36. doi: 10.1111/j.1471-4159.2008.05471.x. Epub 2008 Jul 8. J Neurochem. 2008. PMID: 18627432 Free article.

7

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S. Schilling S, et al. Among authors: heiser u. Nat Med. 2008 Oct;14(10):1106-11. doi: 10.1038/nm.1872. Epub 2008 Sep 28. Nat Med. 2008. PMID: 18836460

8

Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.

Buchholz M, Hamann A, Aust S, Brandt W, Böhme L, Hoffmann T, Schilling S, Demuth HU, Heiser U. Buchholz M, et al. Among authors: heiser u. J Med Chem. 2009 Nov 26;52(22):7069-80. doi: 10.1021/jm900969p. J Med Chem. 2009. PMID: 19863057

9

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Heiser U, Rahfeld JU, Stubbs MT, Schilling S, Demuth HU. Ruiz-Carrillo D, et al. Among authors: heiser u. Biochemistry. 2011 Jul 19;50(28):6280-8. doi: 10.1021/bi200249h. Epub 2011 Jun 27. Biochemistry. 2011. PMID: 21671571

10

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. Cynis H, et al. Among authors: heiser u. EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20. EMBO Mol Med. 2011. PMID: 21774078 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

31 results

Search Page

Filters