Guo Z - Search Results

1

Development of selective, potent RabGGTase inhibitors.

Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS. Stigter EA, et al. Among authors: guo z. J Med Chem. 2012 Oct 11;55(19):8330-40. doi: 10.1021/jm300624s. Epub 2012 Oct 3. J Med Chem. 2012. PMID: 22963166

2

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.

Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H. Guo Z, et al. Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795. Angew Chem Int Ed Engl. 2008. PMID: 18399557 No abstract available.

3

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.

Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W. Guo Z, et al. EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28. EMBO J. 2008. PMID: 18756270 Free PMC article.

4

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.

Tan KT, Guiu-Rozas E, Bon RS, Guo Z, Delon C, Wetzel S, Arndt S, Alexandrov K, Waldmann H, Goody RS, Wu YW, Blankenfeldt W. Tan KT, et al. Among authors: guo z. J Med Chem. 2009 Dec 24;52(24):8025-37. doi: 10.1021/jm901117d. J Med Chem. 2009. PMID: 19894725

5

Structure-guided development of selective RabGGTase inhibitors.

Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H. Bon RS, et al. Among authors: guo z. Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi: 10.1002/anie.201101210. Epub 2011 Apr 21. Angew Chem Int Ed Engl. 2011. PMID: 21520375 No abstract available.

6

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.

Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW. Deraeve C, et al. Among authors: guo z. J Am Chem Soc. 2012 May 2;134(17):7384-91. doi: 10.1021/ja211305j. Epub 2012 Apr 22. J Am Chem Soc. 2012. PMID: 22480322

7

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.

Nguyen UT, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon RS, Blankenfeldt W, Goody RS, Waldmann H, Wolters D, Alexandrov K. Nguyen UT, et al. Among authors: guo z. Nat Chem Biol. 2009 Apr;5(4):227-35. doi: 10.1038/nchembio.149. Epub 2009 Feb 15. Nat Chem Biol. 2009. PMID: 19219049

8

Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism.

Guo Z, Ahmadian MR, Goody RS. Guo Z, et al. Biochemistry. 2005 Nov 29;44(47):15423-9. doi: 10.1021/bi0518601. Biochemistry. 2005. PMID: 16300389

9

Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.

Guo Z, Hou X, Goody RS, Itzen A. Guo Z, et al. J Biol Chem. 2013 Nov 8;288(45):32466-32474. doi: 10.1074/jbc.M113.498329. Epub 2013 Sep 26. J Biol Chem. 2013. PMID: 24072714 Free PMC article.

10

Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI.

Tnimov Z, Guo Z, Gambin Y, Nguyen UT, Wu YW, Abankwa D, Stigter A, Collins BM, Waldmann H, Goody RS, Alexandrov K. Tnimov Z, et al. Among authors: guo z. J Biol Chem. 2012 Aug 3;287(32):26549-62. doi: 10.1074/jbc.M112.371294. Epub 2012 May 24. J Biol Chem. 2012. PMID: 22628549 Free PMC article.

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