Snyder JP - Search Results

1

Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation.

Rey J, Hu H, Kyle F, Lai CF, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AG. Rey J, et al. Among authors: snyder jp. ChemMedChem. 2012 Nov;7(11):1909-14. doi: 10.1002/cmdc.201200307. Epub 2012 Sep 7. ChemMedChem. 2012. PMID: 22961990

2

The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.

Ali S, Heathcote DA, Kroll SH, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, Barrett AG, Coombes RC. Ali S, et al. Among authors: snyder jp. Cancer Res. 2009 Aug 1;69(15):6208-15. doi: 10.1158/0008-5472.CAN-09-0301. Epub 2009 Jul 28. Cancer Res. 2009. PMID: 19638587 Free PMC article.

3

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.

Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali S. Heathcote DA, et al. Among authors: snyder jp. J Med Chem. 2010 Dec 23;53(24):8508-22. doi: 10.1021/jm100732t. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080703

4

Approaches to design non-covalent inhibitors for human granzyme B (hGrB).

Kim MS, Buisson LA, Heathcote DA, Hu H, Braddock DC, Barrett AG, Ashton-Rickardt PG, Snyder JP. Kim MS, et al. Among authors: snyder jp. Org Biomol Chem. 2014 Nov 28;12(44):8952-65. doi: 10.1039/c4ob01874e. Org Biomol Chem. 2014. PMID: 25277547

5

Models for predicting IKKA and IKKB blockade.

Hu H, Snyder JP. Hu H, et al. Among authors: snyder jp. J Chem Inf Model. 2012 Dec 21;52(12):3190-9. doi: 10.1021/ci300287t. Epub 2012 Dec 4. J Chem Inf Model. 2012. PMID: 23157456

6

Organocuprate conjugate addition: the square-planar "CuIII" intermediate.

Hu H, Snyder JP. Hu H, et al. Among authors: snyder jp. J Am Chem Soc. 2007 Jun 13;129(23):7210-1. doi: 10.1021/ja0675346. Epub 2007 May 17. J Am Chem Soc. 2007. PMID: 17506553 No abstract available.

7

Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.

Zhao J, Bane S, Snyder JP, Hu H, Mukherjee K, Slebodnick C, Kingston DG. Zhao J, et al. Among authors: snyder jp. Bioorg Med Chem. 2011 Dec 15;19(24):7664-78. doi: 10.1016/j.bmc.2011.10.010. Epub 2011 Oct 13. Bioorg Med Chem. 2011. PMID: 22071526 Free PMC article.

8

Group A streptococcus inhibitors by high-throughput virtual screening.

Hu H, Mao S, Bugrysheva JV, Pruett S, Liotta DC, Scott JR, Snyder JP. Hu H, et al. Among authors: snyder jp. Eur J Med Chem. 2014 Jul 23;82:120-6. doi: 10.1016/j.ejmech.2014.05.006. Epub 2014 May 4. Eur J Med Chem. 2014. PMID: 24880231

9

Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.

Sun A, Lu YJ, Hu H, Shoji M, Liotta DC, Snyder JP. Sun A, et al. Among authors: snyder jp. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6627-31. doi: 10.1016/j.bmcl.2009.10.023. Epub 2009 Oct 8. Bioorg Med Chem Lett. 2009. PMID: 19854644 Free PMC article.

10

Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.

Sun A, Moore TW, Gunther JR, Kim MS, Rhoden E, Du Y, Fu H, Snyder JP, Katzenellenbogen JA. Sun A, et al. Among authors: snyder jp. ChemMedChem. 2011 Apr 4;6(4):654-66. doi: 10.1002/cmdc.201000507. Epub 2011 Mar 1. ChemMedChem. 2011. PMID: 21365764 Free PMC article.

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