Christopher LJ - Search Results

1

Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.

Xu XS, Dueker SR, Christopher LJ, Lohstroh PN, Keung CF, Cao KK, Bonacorsi SJ, Cojocaru L, Shen JX, Humphreys WG, Stouffer B, Arnold ME. Xu XS, et al. Among authors: christopher lj. Bioanalysis. 2012 Aug;4(15):1855-70. doi: 10.4155/bio.12.171. Bioanalysis. 2012. PMID: 22943617

2

Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: method validation and overcoming specific and non-specific binding at low concentrations.

Xu XS, Demers R, Gu H, Christopher LJ, Su H, Cojocaru L, Boulton DW, Kirby M, Stouffer B, Humphreys WG, Arnold ME. Xu XS, et al. Among authors: christopher lj. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:77-86. doi: 10.1016/j.jchromb.2012.01.033. Epub 2012 Feb 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22349123

3

Simultaneous oral therapeutic and intravenous ¹⁴C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin.

Boulton DW, Kasichayanula S, Keung CF, Arnold ME, Christopher LJ, Xu XS, Lacreta F. Boulton DW, et al. Among authors: christopher lj. Br J Clin Pharmacol. 2013 Mar;75(3):763-8. doi: 10.1111/j.1365-2125.2012.04391.x. Br J Clin Pharmacol. 2013. PMID: 22823746 Free PMC article. Clinical Trial.

4

Sensitivity-based analytical approaches to support human absolute bioavailability studies.

Xu XS, Jiang H, Christopher LJ, Shen JX, Zeng J, Arnold ME. Xu XS, et al. Among authors: christopher lj. Bioanalysis. 2014 Feb;6(4):497-504. doi: 10.4155/bio.13.318. Bioanalysis. 2014. PMID: 24568352

5

A validated LC-MS/MS method for the quantitative measurement of creatinine as an endogenous biomarker in human plasma.

Zhao Y, Liu G, Angeles A, Christopher LJ, Wang Z, Arnold ME, Shen JX. Zhao Y, et al. Among authors: christopher lj. Bioanalysis. 2016 Oct;8(19):1997-2005. doi: 10.4155/bio-2016-0086. Epub 2016 Sep 9. Bioanalysis. 2016. PMID: 27611058

6

Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human.

Su H, Boulton DW, Barros A Jr, Wang L, Cao K, Bonacorsi SJ Jr, Iyer RA, Humphreys WG, Christopher LJ. Su H, et al. Among authors: christopher lj. Drug Metab Dispos. 2012 Jul;40(7):1345-56. doi: 10.1124/dmd.112.045450. Epub 2012 Apr 10. Drug Metab Dispos. 2012. PMID: 22496391

7

Reflecting on a decade of metabolite screening and monitoring.

Aubry AF, Christopher LJ, Wang J, Zhu M, Tirucherai G, Arnold ME. Aubry AF, et al. Among authors: christopher lj. Bioanalysis. 2014 Mar;6(5):651-64. doi: 10.4155/bio.14.19. Bioanalysis. 2014. PMID: 24620807 Review.

8

UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions.

Zheng N, Christopher LJ, Ma X, Ji QC, Buzescu A, Kandoussi H, Garonzik SM, LaCreta F, Aubry AF, Arnold ME, Zeng J. Zheng N, et al. Among authors: christopher lj. Bioanalysis. 2016 Dec;8(23):2429-2443. doi: 10.4155/bio-2016-0227. Bioanalysis. 2016. PMID: 27855510

9

Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections.

Fura A, Khanna A, Vyas V, Koplowitz B, Chang SY, Caporuscio C, Boulton DW, Christopher LJ, Chadwick KD, Hamann LG, Humphreys WG, Kirby M. Fura A, et al. Among authors: christopher lj. Drug Metab Dispos. 2009 Jun;37(6):1164-71. doi: 10.1124/dmd.108.026088. Epub 2009 Feb 27. Drug Metab Dispos. 2009. PMID: 19251818

10

Metabolism and disposition of dasatinib after oral administration to humans.

Christopher LJ, Cui D, Wu C, Luo R, Manning JA, Bonacorsi SJ, Lago M, Allentoff A, Lee FY, McCann B, Galbraith S, Reitberg DP, He K, Barros A Jr, Blackwood-Chirchir A, Humphreys WG, Iyer RA. Christopher LJ, et al. Drug Metab Dispos. 2008 Jul;36(7):1357-64. doi: 10.1124/dmd.107.018267. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420784

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