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Page 1
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β.
Luksch H, Romanowski MJ, Chara O, Tüngler V, Caffarena ER, Heymann MC, Lohse P, Aksentijevich I, Remmers EF, Flecks S, Quoos N, Gramatté J, Petzold C, Hofmann SR, Winkler S, Pessler F, Kallinich T, Ganser G, Nimtz-Talaska A, Baumann U, Runde V, Grimbacher B, Birmelin J, Gahr M, Roesler J, Rösen-Wolff A. Luksch H, et al. Among authors: flecks s. Hum Mutat. 2013 Jan;34(1):122-31. doi: 10.1002/humu.22169. Epub 2012 Aug 10. Hum Mutat. 2013. PMID: 22833538
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.
Heymann MC, Winkler S, Luksch H, Flecks S, Franke M, Ruß S, Ozen S, Yilmaz E, Klein C, Kallinich T, Lindemann D, Brenner S, Ganser G, Roesler J, Rösen-Wolff A, Hofmann SR. Heymann MC, et al. Among authors: flecks s. J Immunol. 2014 May 1;192(9):4379-85. doi: 10.4049/jimmunol.1203524. Epub 2014 Apr 4. J Immunol. 2014. PMID: 24706726
New insights into the mechanism of enzymatic chlorination of tryptophan.
Flecks S, Patallo EP, Zhu X, Ernyei AJ, Seifert G, Schneider A, Dong C, Naismith JH, van Pée KH. Flecks S, et al. Angew Chem Int Ed Engl. 2008;47(49):9533-6. doi: 10.1002/anie.200802466. Angew Chem Int Ed Engl. 2008. PMID: 18979475 Free PMC article. No abstract available.
Biological halogenation has moved far beyond haloperoxidases.
van Pée KH, Dong C, Flecks S, Naismith J, Patallo EP, Wage T. van Pée KH, et al. Among authors: flecks s. Adv Appl Microbiol. 2006;59:127-57. doi: 10.1016/S0065-2164(06)59005-7. Adv Appl Microbiol. 2006. PMID: 16829258 Review. No abstract available.