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The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.
Urban S, Textoris-Taube K, Reimann B, Janek K, Dannenberg T, Ebstein F, Seifert C, Zhao F, Kessler JH, Halenius A, Henklein P, Paschke J, Cadel S, Bernhard H, Ossendorp F, Foulon T, Schadendorf D, Paschen A, Seifert U. Urban S, et al. Among authors: henklein p. J Immunol. 2012 Jul 15;189(2):529-38. doi: 10.4049/jimmunol.1101886. Epub 2012 Jun 15. J Immunol. 2012. PMID: 22706083
The 20S proteasome splicing activity discovered by SpliceMet.
Liepe J, Mishto M, Textoris-Taube K, Janek K, Keller C, Henklein P, Kloetzel PM, Zaikin A. Liepe J, et al. Among authors: henklein p. PLoS Comput Biol. 2010 Jun 24;6(6):e1000830. doi: 10.1371/journal.pcbi.1000830. PLoS Comput Biol. 2010. PMID: 20613855 Free PMC article.
The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.
Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U. Keller M, et al. Among authors: henklein p. Eur J Immunol. 2015 Dec;45(12):3257-68. doi: 10.1002/eji.201445243. Epub 2015 Oct 19. Eur J Immunol. 2015. PMID: 26399368 Free article.
Proteolytic dynamics of human 20S thymoproteasome.
Kuckelkorn U, Stübler S, Textoris-Taube K, Kilian C, Niewienda A, Henklein P, Janek K, Stumpf MPH, Mishto M, Liepe J. Kuckelkorn U, et al. Among authors: henklein p. J Biol Chem. 2019 May 10;294(19):7740-7754. doi: 10.1074/jbc.RA118.007347. Epub 2019 Mar 26. J Biol Chem. 2019. PMID: 30914481 Free PMC article.
Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.
Ebstein F, Textoris-Taube K, Keller C, Golnik R, Vigneron N, Van den Eynde BJ, Schuler-Thurner B, Schadendorf D, Lorenz FK, Uckert W, Urban S, Lehmann A, Albrecht-Koepke N, Janek K, Henklein P, Niewienda A, Kloetzel PM, Mishto M. Ebstein F, et al. Among authors: henklein p. Sci Rep. 2016 Apr 6;6:24032. doi: 10.1038/srep24032. Sci Rep. 2016. PMID: 27049119 Free PMC article.
192 results