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Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Huillard E, et al. Among authors: mcmahon m. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8710-5. doi: 10.1073/pnas.1117255109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586120 Free PMC article.
Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model.
Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, Truong AY, Nicolaides TP, McMahon M, Berger MS, Phillips JJ, James CD, Petritsch CK. Grossauer S, et al. Among authors: mcmahon m. Oncotarget. 2016 Nov 15;7(46):75839-75853. doi: 10.18632/oncotarget.12419. Oncotarget. 2016. PMID: 27713119 Free PMC article.
Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis.
Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, Mann K, Rust AG, Weiss WA, Kinsey CG, Adams DJ, Grossmann A, Mann MB, McMahon M. Vaishnavi A, et al. Among authors: mcmahon m. Cancer Res. 2022 Nov 15;82(22):4261-4273. doi: 10.1158/0008-5472.CAN-21-3214. Cancer Res. 2022. PMID: 36112789 Free PMC article.
Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.
Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B. Yuan P, et al. Among authors: mcmahon m. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18226-31. doi: 10.1073/pnas.1317577110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145418 Free PMC article.
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. Damsky W, et al. Among authors: mcmahon m. Cancer Cell. 2015 Jan 12;27(1):41-56. doi: 10.1016/j.ccell.2014.11.014. Cancer Cell. 2015. PMID: 25584893 Free PMC article.
1,505 results