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Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.
Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR. Kienesberger PC, et al. Among authors: light pe. Mol Cell Biol. 2012 Feb;32(4):740-50. doi: 10.1128/MCB.06470-11. Epub 2011 Dec 12. Mol Cell Biol. 2012. PMID: 22158969 Free PMC article.
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter CC, Clanachan AS, Light PE. Soliman D, et al. Among authors: light pe. J Pharmacol Exp Ther. 2012 Nov;343(2):325-32. doi: 10.1124/jpet.112.196949. Epub 2012 Aug 9. J Pharmacol Exp Ther. 2012. PMID: 22879384
Triton X-100 inhibits L-type voltage-operated calcium channels.
Narang D, Kerr PM, Baserman J, Tam R, Yang W, Searle G, Manning-Fox JE, Paulsen IM, Kozuska JL, MacDonald PE, Light PE, Holt A, Plane F. Narang D, et al. Among authors: light pe. Can J Physiol Pharmacol. 2013 Apr;91(4):316-24. doi: 10.1139/cjpp-2012-0257. Epub 2013 Jan 15. Can J Physiol Pharmacol. 2013. PMID: 23627843
117 results