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Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.
Bioorg Med Chem. 2012 May 15;20(10):3255-62. doi: 10.1016/j.bmc.2012.03.058. Epub 2012 Mar 31.
Bioorg Med Chem. 2012.
PMID: 22522007
Free PMC article.
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M.
Grzegorzewicz AE, et al.
Nat Chem Biol. 2012 Feb 19;8(4):334-41. doi: 10.1038/nchembio.794.
Nat Chem Biol. 2012.
PMID: 22344175
Free PMC article.
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Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.
North EJ, Scherman MS, Bruhn DF, Scarborough JS, Maddox MM, Jones V, Grzegorzewicz A, Yang L, Hess T, Morisseau C, Jackson M, McNeil MR, Lee RE.
North EJ, et al.
Bioorg Med Chem. 2013 May 1;21(9):2587-99. doi: 10.1016/j.bmc.2013.02.028. Epub 2013 Feb 26.
Bioorg Med Chem. 2013.
PMID: 23498915
Free PMC article.
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Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening.
Wang Y, Hess TN, Jones V, Zhou JZ, McNeil MR, Andrew McCammon J.
Wang Y, et al. Among authors: hess tn.
Bioorg Med Chem Lett. 2011 Dec 1;21(23):7064-7. doi: 10.1016/j.bmcl.2011.09.094. Epub 2011 Sep 29.
Bioorg Med Chem Lett. 2011.
PMID: 22014548
Free PMC article.
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Pathogenic nontuberculous mycobacteria resist and inactivate cathelicidin: implication of a novel role for polar mycobacterial lipids.
Honda JR, Hess T, Malcolm KC, Ovrutsky AR, Bai X, Irani VR, Dobos KM, Chan ED, Flores SC.
Honda JR, et al.
PLoS One. 2015 May 18;10(5):e0126994. doi: 10.1371/journal.pone.0126994. eCollection 2015.
PLoS One. 2015.
PMID: 25993058
Free PMC article.
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Nontuberculous Mycobacteria Show Differential Infectivity and Use Phospholipids to Antagonize LL-37.
Honda JR, Hess T, Carlson R, Kandasamy P, Nieto Ramirez LM, Norton GJ, Virdi R, Islam MN, Mehaffy C, Hasan NA, Epperson LE, Hesser D, Alper S, Strong M, Flores SC, Voelker DR, Dobos KM, Chan ED.
Honda JR, et al.
Am J Respir Cell Mol Biol. 2020 Mar;62(3):354-363. doi: 10.1165/rcmb.2018-0278OC.
Am J Respir Cell Mol Biol. 2020.
PMID: 31545652
Free PMC article.
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The Effect of Propofol on Peri-Induction Hemodynamics and Resuscitation in Operative Penetrating Trauma.
Levin JH, Wallace MW, Hess TN, Beavers JR, Chang T, Beyene RT.
Levin JH, et al. Among authors: hess tn.
Am Surg. 2024 Apr;90(4):731-738. doi: 10.1177/00031348231177932. Epub 2023 May 20.
Am Surg. 2024.
PMID: 37209120
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