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Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design.
Nielsen N, Wetterslev J, al-Subaie N, Andersson B, Bro-Jeppesen J, Bishop G, Brunetti I, Cranshaw J, Cronberg T, Edqvist K, Erlinge D, Gasche Y, Glover G, Hassager C, Horn J, Hovdenes J, Johnsson J, Kjaergaard J, Kuiper M, Langørgen J, Macken L, Martinell L, Martner P, Pellis T, Pelosi P, Petersen P, Persson S, Rundgren M, Saxena M, Svensson R, Stammet P, Thorén A, Undén J, Walden A, Wallskog J, Wanscher M, Wise MP, Wyon N, Aneman A, Friberg H. Nielsen N, et al. Among authors: pelosi p. Am Heart J. 2012 Apr;163(4):541-8. doi: 10.1016/j.ahj.2012.01.013. Am Heart J. 2012. PMID: 22520518 Clinical Trial.
The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest: a post hoc analysis of the Target Temperature Management trial.
Annborn M, Bro-Jeppesen J, Nielsen N, Ullén S, Kjaergaard J, Hassager C, Wanscher M, Hovdenes J, Pellis T, Pelosi P, Wise MP, Cronberg T, Erlinge D, Friberg H; TTM-trial investigators. Annborn M, et al. Among authors: pelosi p. Intensive Care Med. 2014 Sep;40(9):1210-9. doi: 10.1007/s00134-014-3375-8. Epub 2014 Jul 8. Intensive Care Med. 2014. PMID: 25001475 Clinical Trial.
Hemodynamics and vasopressor support during targeted temperature management at 33°C Versus 36°C after out-of-hospital cardiac arrest: a post hoc study of the target temperature management trial*.
Bro-Jeppesen J, Annborn M, Hassager C, Wise MP, Pelosi P, Nielsen N, Erlinge D, Wanscher M, Friberg H, Kjaergaard J; TTM Investigators. Bro-Jeppesen J, et al. Among authors: pelosi p. Crit Care Med. 2015 Feb;43(2):318-27. doi: 10.1097/CCM.0000000000000691. Crit Care Med. 2015. PMID: 25365723 Clinical Trial.
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients.
Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU co-authors. Krag M, et al. Among authors: pelosi p. Intensive Care Med. 2015 May;41(5):833-45. doi: 10.1007/s00134-015-3725-1. Epub 2015 Apr 10. Intensive Care Med. 2015. PMID: 25860444
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest.
Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Levin H, Ullén S, Rylander C, Wise MP, Oddo M, Cariou A, Bělohlávek J, Hovdenes J, Saxena M, Kirkegaard H, Young PJ, Pelosi P, Storm C, Taccone FS, Joannidis M, Callaway C, Eastwood GM, Morgan MPG, Nordberg P, Erlinge D, Nichol AD, Chew MS, Hollenberg J, Thomas M, Bewley J, Sweet K, Grejs AM, Christensen S, Haenggi M, Levis A, Lundin A, Düring J, Schmidbauer S, Keeble TR, Karamasis GV, Schrag C, Faessler E, Smid O, Otáhal M, Maggiorini M, Wendel Garcia PD, Jaubert P, Cole JM, Solar M, Borgquist O, Leithner C, Abed-Maillard S, Navarra L, Annborn M, Undén J, Brunetti I, Awad A, McGuigan P, Bjørkholt Olsen R, Cassina T, Vignon P, Langeland H, Lange T, Friberg H, Nielsen N; TTM2 Trial Investigators. Dankiewicz J, et al. Among authors: pelosi p. N Engl J Med. 2021 Jun 17;384(24):2283-2294. doi: 10.1056/NEJMoa2100591. N Engl J Med. 2021. PMID: 34133859 Free article. Clinical Trial.
Effect of Automated Closed-loop ventilation versus convenTional VEntilation on duration and quality of ventilation in critically ill patients (ACTiVE) - study protocol of a randomized clinical trial.
Botta M, Tsonas AM, Sinnige JS, De Bie AJR, Bindels AJGH, Ball L, Battaglini D, Brunetti I, Buiteman-Kruizinga LA, van der Heiden PLJ, de Jonge E, Mojoli F, Robba C, Schoe A, Paulus F, Pelosi P, Neto AS, Horn J, Schultz MJ; ACTiVE collaborative group. Botta M, et al. Among authors: pelosi p. Trials. 2022 Apr 23;23(1):348. doi: 10.1186/s13063-022-06286-w. Trials. 2022. PMID: 35461264 Free PMC article.
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial.
Robba C, Badenes R, Battaglini D, Ball L, Brunetti I, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia PD, Young PJ, Eastwood G, Chew MS, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Annborn M, Solar M, Taccone FS, Dankiewicz J, Nielsen N, Pelosi P; TTM2 Trial Collaborators. Robba C, et al. Among authors: pelosi p. Intensive Care Med. 2022 Aug;48(8):1024-1038. doi: 10.1007/s00134-022-06756-4. Epub 2022 Jul 2. Intensive Care Med. 2022. PMID: 35780195 Free PMC article.
Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial.
Simpson RFG, Dankiewicz J, Karamasis GV, Pelosi P, Haenggi M, Young PJ, Jakobsen JC, Bannard-Smith J, Wendel-Garcia PD, Taccone FS, Nordberg P, Wise MP, Grejs AM, Lilja G, Olsen RB, Cariou A, Lascarrou JB, Saxena M, Hovdenes J, Thomas M, Friberg H, Davies JR, Nielsen N, Keeble TR. Simpson RFG, et al. Among authors: pelosi p. Crit Care. 2022 Nov 15;26(1):356. doi: 10.1186/s13054-022-04231-6. Crit Care. 2022. PMID: 36380332 Free PMC article. Clinical Trial.
Evolution of mechanical ventilation in response to clinical research.
Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, González M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montañez AM, Anzueto A; VENTILA Group. Esteban A, et al. Among authors: pelosi p. Am J Respir Crit Care Med. 2008 Jan 15;177(2):170-7. doi: 10.1164/rccm.200706-893OC. Epub 2007 Oct 25. Am J Respir Crit Care Med. 2008. PMID: 17962636 Review.
Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS: A Randomized Clinical Trial.
Writing Committee and Steering Committee for the RELAx Collaborative Group; Algera AG, Pisani L, Serpa Neto A, den Boer SS, Bosch FFH, Bruin K, Klooster PM, Van der Meer NJM, Nowitzky RO, Purmer IM, Slabbekoorn M, Spronk PE, van Vliet J, Weenink JJ, Gama de Abreu M, Pelosi P, Schultz MJ, Paulus F. Writing Committee and Steering Committee for the RELAx Collaborative Group, et al. Among authors: pelosi p. JAMA. 2020 Dec 22;324(24):2509-2520. doi: 10.1001/jama.2020.23517. JAMA. 2020. PMID: 33295981 Free PMC article. Clinical Trial.
1,052 results