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New anti-tuberculosis agents amongst known drugs.
Lougheed KE, Taylor DL, Osborne SA, Bryans JS, Buxton RS. Lougheed KE, et al. Among authors: buxton rs. Tuberculosis (Edinb). 2009 Sep;89(5):364-70. doi: 10.1016/j.tube.2009.07.002. Epub 2009 Aug 20. Tuberculosis (Edinb). 2009. PMID: 19699151 Free PMC article.
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS. Lougheed KE, et al. Among authors: buxton rs. Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/j.tube.2011.03.005. Epub 2011 Apr 11. Tuberculosis (Edinb). 2011. PMID: 21482481 Free PMC article.
An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon.
Spivey VL, Whalan RH, Hirst EM, Smerdon SJ, Buxton RS. Spivey VL, et al. Among authors: buxton rs. FEMS Microbiol Lett. 2013 Oct;347(2):107-15. doi: 10.1111/1574-6968.12230. Epub 2013 Aug 23. FEMS Microbiol Lett. 2013. PMID: 23915284 Free PMC article.
Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence.
Smith LJ, Bochkareva A, Rolfe MD, Hunt DM, Kahramanoglou C, Braun Y, Rodgers A, Blockley A, Coade S, Lougheed KEA, Hafneh NA, Glenn SM, Crack JC, Le Brun NE, Saldanha JW, Makarov V, Nobeli I, Arnvig K, Mukamolova GV, Buxton RS, Green J. Smith LJ, et al. Among authors: buxton rs. Nucleic Acids Res. 2017 Jun 20;45(11):6600-6612. doi: 10.1093/nar/gkx406. Nucleic Acids Res. 2017. PMID: 28482027 Free PMC article.
106 results