Chan CH - Search Results

1

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, Jeong YS, Yuan X, Khanna KK, Jin J, Zeng YX, Lin HK. Wu J, et al. Among authors: chan ch. Mol Cell. 2012 May 11;46(3):351-61. doi: 10.1016/j.molcel.2012.02.018. Epub 2012 Mar 29. Mol Cell. 2012. PMID: 22464731 Free PMC article.

2

Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.

Xu D, Li CF, Zhang X, Gong Z, Chan CH, Lee SW, Jin G, Rezaeian AH, Han F, Wang J, Yang WL, Feng ZZ, Chen W, Wu CY, Wang YJ, Chow LP, Zhu XF, Zeng YX, Lin HK. Xu D, et al. Among authors: chan ch. Nat Commun. 2015 Mar 30;6:6641. doi: 10.1038/ncomms7641. Nat Commun. 2015. PMID: 25818643 Free PMC article.

3

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.

Jin G, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov dos D, Ho YS, Lin HK. Jin G, et al. Among authors: chan ch. Mol Cell. 2015 Jun 18;58(6):989-1000. doi: 10.1016/j.molcel.2015.05.010. Epub 2015 Jun 4. Mol Cell. 2015. PMID: 26051179 Free PMC article.

4

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.

Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Chan CH, et al. Nat Cell Biol. 2010 May;12(5):457-67. doi: 10.1038/ncb2047. Epub 2010 Apr 11. Nat Cell Biol. 2010. PMID: 20383141 Free PMC article.

5

Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.

Wu CY, Kang HY, Yang WL, Wu J, Jeong YS, Wang J, Chan CH, Lee SW, Zhang X, Lamothe B, Campos AD, Darnay BG, Lin HK. Wu CY, et al. Among authors: chan ch. J Biol Chem. 2011 Sep 2;286(35):30806-30815. doi: 10.1074/jbc.M111.257469. Epub 2011 Jun 20. J Biol Chem. 2011. PMID: 21690091 Free PMC article.

6

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. Chan CH, et al. Cell. 2012 May 25;149(5):1098-111. doi: 10.1016/j.cell.2012.02.065. Cell. 2012. PMID: 22632973 Free PMC article.

7

E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing.

Wang J, Han F, Lee SW, Wu J, Chan CH, Zhang X, Gao Y, Su HK, Feng ZZ, Xu DZ, Lin HK. Wang J, et al. Among authors: chan ch. Biochem Biophys Res Commun. 2014 Mar 14;445(3):566-71. doi: 10.1016/j.bbrc.2014.02.042. Epub 2014 Feb 18. Biochem Biophys Res Commun. 2014. PMID: 24561244

8

Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.

Lee SW, Li CF, Jin G, Cai Z, Han F, Chan CH, Yang WL, Li BK, Rezaeian AH, Li HY, Huang HY, Lin HK. Lee SW, et al. Among authors: chan ch. Mol Cell. 2015 Mar 19;57(6):1022-1033. doi: 10.1016/j.molcel.2015.01.015. Epub 2015 Feb 26. Mol Cell. 2015. PMID: 25728766 Free PMC article.

9

Regulation of Skp2 expression and activity and its role in cancer progression.

Chan CH, Lee SW, Wang J, Lin HK. Chan CH, et al. ScientificWorldJournal. 2010 Jun 1;10:1001-15. doi: 10.1100/tsw.2010.89. ScientificWorldJournal. 2010. PMID: 20526532 Free PMC article. Review.

10

Novel ARF/p53-independent senescence pathways in cancer repression.

Chan CH, Gao Y, Moten A, Lin HK. Chan CH, et al. J Mol Med (Berl). 2011 Sep;89(9):857-67. doi: 10.1007/s00109-011-0766-y. Epub 2011 May 19. J Mol Med (Berl). 2011. PMID: 21594579 Free PMC article. Review.

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