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Page 1
5a-Carba-β-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Ohtake Y, Sato T, Matsuoka H, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Higuchi T, Murakata M, Kobayashi T, Morikawa K, Shimma N, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S. Ohtake Y, et al. Among authors: hagita h. Bioorg Med Chem. 2011 Sep 15;19(18):5334-41. doi: 10.1016/j.bmc.2011.08.005. Epub 2011 Aug 8. Bioorg Med Chem. 2011. PMID: 21873071
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Ohtake Y, Sato T, Matsuoka H, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Higuchi T, Murakata M, Morikawa K, Shimma N, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S. Ohtake Y, et al. Among authors: hagita h. Bioorg Med Chem. 2012 Jul 1;20(13):4117-27. doi: 10.1016/j.bmc.2012.04.053. Epub 2012 May 4. Bioorg Med Chem. 2012. PMID: 22652255
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
Ohtake Y, Sato T, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Yamaguchi M, Takami K, Yeu SY, Ahn KH, Matsuoka H, Morikawa K, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S. Ohtake Y, et al. Among authors: hagita h. J Med Chem. 2012 Sep 13;55(17):7828-40. doi: 10.1021/jm300884k. Epub 2012 Aug 28. J Med Chem. 2012. PMID: 22889351
In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP.
Yamane M, Kawashima K, Yamaguchi K, Nagao S, Sato M, Suzuki M, Honda K, Hagita H, Kuhlmann O, Poirier A, Fowler S, Funk C, Simon S, Aso Y, Ikeda S, Ishigai M. Yamane M, et al. Among authors: hagita h. Xenobiotica. 2015 Mar;45(3):230-8. doi: 10.3109/00498254.2014.976296. Epub 2014 Oct 28. Xenobiotica. 2015. PMID: 25350082
27 results