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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. Poulikakos PI, et al. Among authors: ng c. Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662. Nature. 2011. PMID: 22113612 Free PMC article.
A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition.
Shi H, Hong A, Kong X, Koya RC, Song C, Moriceau G, Hugo W, Yu CC, Ng C, Chodon T, Scolyer RA, Kefford RF, Ribas A, Long GV, Lo RS. Shi H, et al. Among authors: ng c. Cancer Discov. 2014 Jan;4(1):69-79. doi: 10.1158/2159-8290.CD-13-0279. Epub 2013 Nov 21. Cancer Discov. 2014. PMID: 24265152 Free PMC article.
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.
Hou S, Zhao L, Shen Q, Yu J, Ng C, Kong X, Wu D, Song M, Shi X, Xu X, OuYang WH, He R, Zhao XZ, Lee T, Brunicardi FC, Garcia MA, Ribas A, Lo RS, Tseng HR. Hou S, et al. Among authors: ng c. Angew Chem Int Ed Engl. 2013 Mar 18;52(12):3379-83. doi: 10.1002/anie.201208452. Epub 2013 Feb 21. Angew Chem Int Ed Engl. 2013. PMID: 23436302 Free PMC article. No abstract available.
Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
Atefi M, Titz B, Avramis E, Ng C, Wong DJ, Lassen A, Cerniglia M, Escuin-Ordinas H, Foulad D, Comin-Anduix B, Graeber TG, Ribas A. Atefi M, et al. Among authors: ng c. Mol Cancer. 2015 Feb 3;14(1):27. doi: 10.1186/s12943-015-0293-5. Mol Cancer. 2015. PMID: 25645078 Free PMC article.
CRAF R391W is a melanoma driver oncogene.
Atefi M, Titz B, Tsoi J, Avramis E, Le A, Ng C, Lomova A, Lassen A, Friedman M, Chmielowski B, Ribas A, Graeber TG. Atefi M, et al. Among authors: ng c. Sci Rep. 2016 Jun 8;6:27454. doi: 10.1038/srep27454. Sci Rep. 2016. PMID: 27273450 Free PMC article.
6,131 results