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The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.
Maksimovic-Ivanic D, Mijatovic S, Miljkovic D, Harhaji-Trajkovic L, Timotijevic G, Mojic M, Dabideen D, Cheng KF, McCubrey JA, Mangano K, Al-Abed Y, Libra M, Garotta G, Stosic-Grujicic S, Nicoletti F. Maksimovic-Ivanic D, et al. Mol Cancer Ther. 2009 May;8(5):1169-78. doi: 10.1158/1535-7163.MCT-08-0998. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417156
In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells.
Donia M, Maksimovic-Ivanic D, Mijatovic S, Mojic M, Miljkovic D, Timotijevic G, Fagone P, Caponnetto S, Al-Abed Y, McCubrey J, Stosic-Grujicic S, Nicoletti F. Donia M, et al. Cell Cycle. 2011 Feb 1;10(3):492-9. doi: 10.4161/cc.10.3.14727. Epub 2011 Feb 1. Cell Cycle. 2011. PMID: 21270522
Resistance to TRAIL and how to surmount it.
Maksimovic-Ivanic D, Stosic-Grujicic S, Nicoletti F, Mijatovic S. Maksimovic-Ivanic D, et al. Immunol Res. 2012 Apr;52(1-2):157-68. doi: 10.1007/s12026-012-8284-8. Immunol Res. 2012. PMID: 22407575 Review.
Therapeutic potential of nitric oxide-modified drugs in colon cancer cells.
Mojic M, Mijatovic S, Maksimovic-Ivanic D, Miljkovic D, Stosic-Grujicic S, Stankovic M, Mangano K, Travali S, Donia M, Fagone P, Zocca MB, Al-Abed Y, McCubrey JA, Nicoletti F. Mojic M, et al. Mol Pharmacol. 2012 Oct;82(4):700-10. doi: 10.1124/mol.112.077842. Epub 2012 Jul 13. Mol Pharmacol. 2012. PMID: 22798453
Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis.
Petković F, Blaževski J, Momčilović M, Timotijević G, Zocca MB, Mijatović S, Maksimović-Ivanić D, Mangano K, Fagone P, Stošić-Grujičić S, Nicoletti F, Miljković D. Petković F, et al. J Neuroimmunol. 2013 Jun 15;259(1-2):55-65. doi: 10.1016/j.jneuroim.2013.03.010. Epub 2013 Apr 18. J Neuroimmunol. 2013. PMID: 23602714
Multiple antimelanoma potential of dry olive leaf extract.
Mijatovic SA, Timotijevic GS, Miljkovic DM, Radovic JM, Maksimovic-Ivanic DD, Dekanski DP, Stosic-Grujicic SD. Mijatovic SA, et al. Int J Cancer. 2011 Apr 15;128(8):1955-65. doi: 10.1002/ijc.25526. Int J Cancer. 2011. PMID: 20568104
A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice.
Stosic-Grujicic S, Cvetkovic I, Mangano K, Fresta M, Maksimovic-Ivanic D, Harhaji L, Popadic D, Momcilovic M, Miljkovic D, Kim J, Al-Abed Y, Nicoletti F. Stosic-Grujicic S, et al. J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49. doi: 10.1124/jpet.106.109272. Epub 2006 Dec 5. J Pharmacol Exp Ther. 2007. PMID: 17148780
134 results