Lea WA - Search Results

1

Fluorescence polarization assays in small molecule screening.

Lea WA, Simeonov A. Lea WA, et al. Expert Opin Drug Discov. 2011 Jan;6(1):17-32. doi: 10.1517/17460441.2011.537322. Expert Opin Drug Discov. 2011. PMID: 22328899 Free PMC article.

2

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. Lea WA, et al. Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149. Assay Drug Dev Technol. 2008. PMID: 18665782 Free PMC article.

3

A high-throughput approach for identification of novel general anesthetics.

Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. Lea WA, et al. PLoS One. 2009 Sep 24;4(9):e7150. doi: 10.1371/journal.pone.0007150. PLoS One. 2009. PMID: 19777064 Free PMC article.

4

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: lea wa. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

5

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Marugan JJ, et al. Among authors: lea wa. J Med Chem. 2011 Feb 24;54(4):1033-58. doi: 10.1021/jm1008902. Epub 2011 Jan 20. J Med Chem. 2011. PMID: 21250698 Free PMC article.

6

Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.

Lea WA, Simeonov A. Lea WA, et al. PLoS One. 2012;7(4):e36219. doi: 10.1371/journal.pone.0036219. Epub 2012 Apr 30. PLoS One. 2012. PMID: 22558390 Free PMC article.

7

Non-iminosugar glucocerebrosidase small molecule chaperones.

Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E. Marugan JJ, et al. Among authors: lea wa. Medchemcomm. 2012 Jan;3(1):56-60. doi: 10.1039/C1MD00200G. Epub 2011 Oct 24. Medchemcomm. 2012. PMID: 22606365 Free PMC article.

8

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne N, Shen M, Lea WA, Simeonov A, Lovell S, Auld DS, Inglese J. Thorne N, et al. Among authors: lea wa. Chem Biol. 2012 Aug 24;19(8):1060-72. doi: 10.1016/j.chembiol.2012.07.015. Chem Biol. 2012. PMID: 22921073 Free PMC article.

9

Biochemical assays for the discovery of TDP1 inhibitors.

Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Among authors: lea wa. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.

10

Discovery of a novel general anesthetic chemotype using high-throughput screening.

McKinstry-Wu AR, Bu W, Rai G, Lea WA, Weiser BP, Liang DF, Simeonov A, Jadhav A, Maloney DJ, Eckenhoff RG. McKinstry-Wu AR, et al. Among authors: lea wa. Anesthesiology. 2015 Feb;122(2):325-33. doi: 10.1097/ALN.0000000000000505. Anesthesiology. 2015. PMID: 25603205 Free PMC article.

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