Karki RG - Search Results

1

PDB ligand conformational energies calculated quantum-mechanically.

Sitzmann M, Weidlich IE, Filippov IV, Liao C, Peach ML, Ihlenfeldt WD, Karki RG, Borodina YV, Cachau RE, Nicklaus MC. Sitzmann M, et al. Among authors: karki rg. J Chem Inf Model. 2012 Mar 26;52(3):739-56. doi: 10.1021/ci200595n. Epub 2012 Feb 21. J Chem Inf Model. 2012. PMID: 22303903 Free PMC article.

2

Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.

Liao C, Karki RG, Marchand C, Pommier Y, Nicklaus MC. Liao C, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5361-5. doi: 10.1016/j.bmcl.2007.08.011. Epub 2007 Aug 11. Bioorg Med Chem Lett. 2007. PMID: 17719223

3

Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.

Karki RG, Tang Y, Burke TR Jr, Nicklaus MC. Karki RG, et al. J Comput Aided Mol Des. 2004 Dec;18(12):739-60. doi: 10.1007/s10822-005-0365-5. Epub 2005 Jun 27. J Comput Aided Mol Des. 2004. PMID: 16075307

4

Comprehensive structural studies of 2',3'-difluorinated nucleosides: comparison of theory, solution, and solid state.

Barchi JJ Jr, Karki RG, Nicklaus MC, Siddiqui MA, George C, Mikhailopulo IA, Marquez VE. Barchi JJ Jr, et al. Among authors: karki rg. J Am Chem Soc. 2008 Jul 16;130(28):9048-57. doi: 10.1021/ja800964g. Epub 2008 Jun 18. J Am Chem Soc. 2008. PMID: 18558684 Free PMC article.

5

Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.

Oishi S, Karki RG, Kang SU, Wang X, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: karki rg. J Med Chem. 2005 Feb 10;48(3):764-72. doi: 10.1021/jm0492709. J Med Chem. 2005. PMID: 15689160

6

Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.

Choi WJ, Shi ZD, Worthy KM, Bindu L, Karki RG, Nicklaus MC, Fisher RJ, Burke TR Jr. Choi WJ, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5265-9. doi: 10.1016/j.bmcl.2006.08.004. Bioorg Med Chem Lett. 2006. PMID: 16908148 Free PMC article.

7

Utilization of a common pathway for the synthesis of high affinity macrocyclic Grb2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction.

Shi ZD, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Shi ZD, et al. Among authors: karki rg. Chem Biodivers. 2005 Apr;2(4):447-56. doi: 10.1002/cbdv.200590024. Chem Biodivers. 2005. PMID: 17191992

8

Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides.

Kang SU, Choi WJ, Oishi S, Lee K, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Kang SU, et al. Among authors: karki rg. J Med Chem. 2007 Apr 19;50(8):1978-82. doi: 10.1021/jm0614073. Epub 2007 Mar 20. J Med Chem. 2007. PMID: 17371004

9

Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.

Shi ZD, Karki RG, Oishi S, Worthy KM, Bindu LK, Dharmawardana PG, Nicklaus MC, Bottaro DP, Fisher RJ, Burke TR Jr. Shi ZD, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1385-8. doi: 10.1016/j.bmcl.2005.01.017. Bioorg Med Chem Lett. 2005. PMID: 15713392

10

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.

Zhang X, Pais GC, Svarovskaia ES, Marchand C, Johnson AA, Karki RG, Nicklaus MC, Pathak VK, Pommier Y, Burke TR. Zhang X, et al. Among authors: karki rg. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1215-9. doi: 10.1016/s0960-894x(03)00059-3. Bioorg Med Chem Lett. 2003. PMID: 12643946

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