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Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas.
Abbruzzese C, Mattarocci S, Pizzuti L, Mileo AM, Visca P, Antoniani B, Alessandrini G, Facciolo F, Amato R, D'Antona L, Rinaldi M, Felsani A, Perrotti N, Paggi MG. Abbruzzese C, et al. Among authors: amato r. J Exp Clin Cancer Res. 2012 Jan 12;31(1):4. doi: 10.1186/1756-9966-31-4. J Exp Clin Cancer Res. 2012. PMID: 22240294 Free PMC article.
Relative resistance of SGK1 knockout mice against chemical carcinogenesis.
Nasir O, Wang K, Föller M, Gu S, Bhandaru M, Ackermann TF, Boini KM, Mack A, Klingel K, Amato R, Perrotti N, Kuhl D, Behrens J, Stournaras C, Lang F. Nasir O, et al. Among authors: amato r. IUBMB Life. 2009 Jul;61(7):768-76. doi: 10.1002/iub.209. IUBMB Life. 2009. PMID: 19548318 Free article.
60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC.
Menniti M, Iuliano R, Föller M, Sopjani M, Alesutan I, Mariggiò S, Nofziger C, Perri AM, Amato R, Blazer-Yost B, Corda D, Lang F, Perrotti N. Menniti M, et al. Among authors: amato r. Cell Physiol Biochem. 2010;26(4-5):587-96. doi: 10.1159/000322326. Epub 2010 Oct 29. Cell Physiol Biochem. 2010. PMID: 21063096 Free article.
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold.
Ortuso F, Amato R, Artese A, D'antona L, Costa G, Talarico C, Gigliotti F, Bianco C, Trapasso F, Schenone S, Musumeci F, Botta L, Perrotti N, Alcaro S. Ortuso F, et al. Among authors: amato r. J Chem Inf Model. 2014 Jul 28;54(7):1828-32. doi: 10.1021/ci500235f. Epub 2014 Jun 13. J Chem Inf Model. 2014. PMID: 24896223
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.
D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N. D'Antona L, et al. Among authors: amato r. Cell Physiol Biochem. 2015;35(5):2006-18. doi: 10.1159/000374008. Epub 2015 Mar 27. Cell Physiol Biochem. 2015. PMID: 25871776 Free article.
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.
Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: amato r. Oncotarget. 2015 Nov 10;6(35):37511-25. doi: 10.18632/oncotarget.5527. Oncotarget. 2015. PMID: 26462020 Free PMC article.
741 results