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Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Suchiman HE, Jacobsen R, McGue M, Stevnsner T, Bohr VA, de Craen AJ, Westendorp RG, Schreiber S, Slagboom PE, Nebel A, Vaupel JW, Christensen K, Christiansen L. Soerensen M, et al. Among authors: kleindorp r. Age (Dordr). 2013 Apr;35(2):487-500. doi: 10.1007/s11357-011-9373-7. Epub 2012 Jan 12. Age (Dordr). 2013. PMID: 22234866 Free PMC article.
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Jacobsen R, Suchiman HE, de Craen AJ, Westendorp RG, Schreiber S, Stevnsner T, Bohr VA, Slagboom PE, Nebel A, Vaupel JW, Christensen K, McGue M, Christiansen L. Soerensen M, et al. Among authors: kleindorp r. Exp Gerontol. 2012 May;47(5):379-87. doi: 10.1016/j.exger.2012.02.010. Epub 2012 Mar 3. Exp Gerontol. 2012. PMID: 22406557 Free PMC article.
Association of FOXO3A variation with human longevity confirmed in German centenarians.
Flachsbart F, Caliebe A, Kleindorp R, Blanché H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A. Flachsbart F, et al. Among authors: kleindorp r. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2700-5. doi: 10.1073/pnas.0809594106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196970 Free PMC article.
Association of TH01 with human longevity revisited.
von Wurmb-Schwark N, Caliebe A, Schwark T, Kleindorp R, Poetsch M, Schreiber S, Nebel A. von Wurmb-Schwark N, et al. Among authors: kleindorp r. Eur J Hum Genet. 2011 Aug;19(8):924-7. doi: 10.1038/ejhg.2011.43. Epub 2011 Mar 16. Eur J Hum Genet. 2011. PMID: 21407269 Free PMC article.
14 results