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The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1019-22. doi: 10.1016/j.bmcl.2011.11.127. Epub 2011 Dec 9.
Bioorg Med Chem Lett. 2012.
PMID: 22222034
Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain.
Yang SW, Smotryski J, Matasi J, Ho G, Tulshian D, Greenlee WJ, Brusa R, Beltramo M, Cox K.
Yang SW, et al. Among authors: smotryski j.
Bioorg Med Chem Lett. 2011 Jan 1;21(1):182-5. doi: 10.1016/j.bmcl.2010.11.044. Epub 2010 Nov 11.
Bioorg Med Chem Lett. 2011.
PMID: 21115245
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Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Yang SW, Smotryski J, McElroy WT, Tan Z, Ho G, Tulshian D, Greenlee WJ, Guzzi M, Zhang X, Mullins D, Xiao L, Hruza A, Chan TM, Rindgen D, Bleickardt C, Hodgson R.
Yang SW, et al. Among authors: smotryski j.
Bioorg Med Chem Lett. 2012 Jan 1;22(1):235-9. doi: 10.1016/j.bmcl.2011.11.023. Epub 2011 Nov 16.
Bioorg Med Chem Lett. 2012.
PMID: 22142545
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Pyrazoloquinolines as PDE10A inhibitors: discovery of a tool compound.
McElroy WT, Tan Z, Basu K, Yang SW, Smotryski J, Ho GD, Tulshian D, Greenlee WJ, Mullins D, Guzzi M, Zhang X, Bleickardt C, Hodgson R.
McElroy WT, et al. Among authors: smotryski j.
Bioorg Med Chem Lett. 2012 Feb 1;22(3):1335-9. doi: 10.1016/j.bmcl.2011.12.080. Epub 2011 Dec 21.
Bioorg Med Chem Lett. 2012.
PMID: 22227212
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