Thorne CA - Search Results

1

Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.

Ni TT, Rellinger EJ, Mukherjee A, Xie S, Stephens L, Thorne CA, Kim K, Hu J, Lee E, Marnett L, Hatzopoulos AK, Zhong TP. Ni TT, et al. Among authors: thorne ca. Chem Biol. 2011 Dec 23;18(12):1658-68. doi: 10.1016/j.chembiol.2011.09.015. Chem Biol. 2011. PMID: 22195568 Free PMC article.

2

Lrp6 is required for convergent extension during Xenopus gastrulation.

Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E. Tahinci E, et al. Among authors: thorne ca. Development. 2007 Nov;134(22):4095-106. doi: 10.1242/dev.010272. Development. 2007. PMID: 17965054 Free PMC article.

3

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.

Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E. Cselenyi CS, et al. Among authors: thorne ca. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8032-7. doi: 10.1073/pnas.0803025105. Epub 2008 May 28. Proc Natl Acad Sci U S A. 2008. PMID: 18509060 Free PMC article.

4

sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair.

Alfaro MP, Vincent A, Saraswati S, Thorne CA, Hong CC, Lee E, Young PP. Alfaro MP, et al. Among authors: thorne ca. J Biol Chem. 2010 Nov 12;285(46):35645-53. doi: 10.1074/jbc.M110.135335. Epub 2010 Sep 7. J Biol Chem. 2010. PMID: 20826809 Free PMC article.

5

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM 3rd, Lee E. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36. doi: 10.1038/nchembio.453. Epub 2010 Oct 3. Nat Chem Biol. 2010. PMID: 20890287 Free PMC article.

6

Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.

Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP. Saraswati S, et al. Among authors: thorne ca. PLoS One. 2010 Nov 29;5(11):e15521. doi: 10.1371/journal.pone.0015521. PLoS One. 2010. PMID: 21170416 Free PMC article.

7

Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs.

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Hang BI, et al. Among authors: thorne ca. Bioorg Med Chem. 2012 Mar 15;20(6):1869-77. doi: 10.1016/j.bmc.2011.12.044. Epub 2011 Dec 30. Bioorg Med Chem. 2012. PMID: 22261025 Free PMC article. Review.

8

The way Wnt works: components and mechanism.

Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E. Saito-Diaz K, et al. Among authors: thorne ca. Growth Factors. 2013 Feb;31(1):1-31. doi: 10.3109/08977194.2012.752737. Epub 2012 Dec 21. Growth Factors. 2013. PMID: 23256519 Free PMC article. Review.

9

Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen.

Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Hao J, et al. Among authors: thorne ca. Cell Rep. 2013 Sep 12;4(5):898-904. doi: 10.1016/j.celrep.2013.07.047. Epub 2013 Sep 5. Cell Rep. 2013. PMID: 24012757 Free PMC article.

10

USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.

Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E. Kassel S, et al. Among authors: thorne ca. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7. Sci Signal. 2023. PMID: 36749823 Free PMC article.

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