Zheng JJ - Search Results

1

Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies.

Shan J, Zhang X, Bao J, Cassell R, Zheng JJ. Shan J, et al. Among authors: zheng jj. Chem Biol Drug Des. 2012 Apr;79(4):376-83. doi: 10.1111/j.1747-0285.2011.01295.x. Epub 2012 Jan 30. Chem Biol Drug Des. 2012. PMID: 22172211 Free PMC article.

2

Optimizing Dvl PDZ domain inhibitor by exploring chemical space.

Shan J, Zheng JJ. Shan J, et al. Among authors: zheng jj. J Comput Aided Mol Des. 2009 Jan;23(1):37-47. doi: 10.1007/s10822-008-9236-1. Epub 2008 Sep 9. J Comput Aided Mol Des. 2009. PMID: 18780146 Free PMC article.

3

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

Grandy D, Shan J, Zhang X, Rao S, Akunuru S, Li H, Zhang Y, Alpatov I, Zhang XA, Lang RA, Shi DL, Zheng JJ. Grandy D, et al. Among authors: zheng jj. J Biol Chem. 2009 Jun 12;284(24):16256-16263. doi: 10.1074/jbc.M109.009647. Epub 2009 Apr 21. J Biol Chem. 2009. PMID: 19383605 Free PMC article.

4

Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.

Shan J, Zheng JJ. Shan J, et al. Among authors: zheng jj. Methods Mol Biol. 2012;928:17-28. doi: 10.1007/978-1-62703-008-3_2. Methods Mol Biol. 2012. PMID: 22956130 Free PMC article.

5

Identification of a specific inhibitor of the dishevelled PDZ domain.

Shan J, Shi DL, Wang J, Zheng J. Shan J, et al. Biochemistry. 2005 Nov 29;44(47):15495-503. doi: 10.1021/bi0512602. Biochemistry. 2005. PMID: 16300398

6

Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.

Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ. Chen L, et al. Among authors: zheng jj. J Biol Chem. 2008 Aug 22;283(34):23364-70. doi: 10.1074/jbc.M802375200. Epub 2008 Jun 3. J Biol Chem. 2008. PMID: 18524778 Free PMC article.

7

The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.

Bao J, Zheng JJ, Wu D. Bao J, et al. Among authors: zheng jj. Sci Signal. 2012 May 15;5(224):pe22. doi: 10.1126/scisignal.2003028. Sci Signal. 2012. PMID: 22589387 Free PMC article.

8

Genome-wide network analysis of Wnt signaling in three pediatric cancers.

Bao J, Lee HJ, Zheng JJ. Bao J, et al. Among authors: zheng jj. Sci Rep. 2013 Oct 17;3:2969. doi: 10.1038/srep02969. Sci Rep. 2013. PMID: 24132329 Free PMC article.

9

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.

Rana R, Carroll CE, Lee HJ, Bao J, Marada S, Grace CR, Guibao CD, Ogden SK, Zheng JJ. Rana R, et al. Among authors: zheng jj. Nat Commun. 2013;4:2965. doi: 10.1038/ncomms3965. Nat Commun. 2013. PMID: 24351982 Free PMC article.

10

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.

Lee HJ, Bao J, Miller A, Zhang C, Wu J, Baday YC, Guibao C, Li L, Wu D, Zheng JJ. Lee HJ, et al. Among authors: zheng jj. J Biol Chem. 2015 Dec 18;290(51):30596-606. doi: 10.1074/jbc.M115.673202. Epub 2015 Oct 26. J Biol Chem. 2015. PMID: 26504084 Free PMC article.

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